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Epiduo and Clindesse drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epiduo (adapalene; benzoyl peroxide) and Clindesse (clindamycin phosphate). Common drug interactions include post procedural complication among females.

The phase IV clinical study analyzes what interactions people have when they take Epiduo and Clindesse. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Epiduo?

Epiduo has active ingredients of adapalene; benzoyl peroxide. It is often used in acne. eHealthMe is studying from 1,581 Epiduo users. Check the latest studies of Epiduo.

What is Clindesse?

Clindesse has active ingredients of clindamycin phosphate. eHealthMe is studying from 202 Clindesse users. Check the latest studies of Clindesse.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

15 people who take Epiduo and Clindesse together, and have interactions are studied.

Epiduo and Clindesse drug interactions.

What are the common drug interactions of Epiduo and Clindesse, by gender? *:

female:

  1. Post procedural complication
  2. Colitis (inflammation of colon)
  3. Vitamin d decreased
  4. Blood oestrogen decreased
  5. Blood testosterone decreased
  6. Muscle twitching
  7. Progesterone decreased
  8. Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
  9. Colitis ulcerative (inflammation of colon with ulcer)
  10. Lyme disease (a bacterial infection that is spread to humans by infected ticks)

male:

n/a

What are the common drug interactions of Epiduo and Clindesse, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Post procedural complication
  2. Colitis (inflammation of colon)
  3. Retching (strong involuntary effort to vomit)
  4. Skin irritation
  5. Urethral polyp

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 93.33%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 14 people, 93.33%

* Approximation only. Some reports may have incomplete information.

Do you take Epiduo and Clindesse?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Epiduo and Clindesse:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Epiduo:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Clindesse:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Epiduo and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Clindesse and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on adapalene; benzoyl peroxide and clindamycin phosphate (the active ingredients of Epiduo and Clindesse, respectively), and Epiduo and Clindesse (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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