Epiduo and Wellbutrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epiduo (adapalene; benzoyl peroxide) and Wellbutrin (bupropion hydrochloride). Common drug interactions include drug effect decreased among females and optic neuropathy among males.

The phase IV clinical study analyzes what interactions people have when they take Epiduo and Wellbutrin. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Epiduo?

Epiduo has active ingredients of adapalene; benzoyl peroxide. It is often used in acne. eHealthMe is studying from 1,581 Epiduo users. Check the latest studies of Epiduo.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,110 Wellbutrin users. Check the latest studies of Wellbutrin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 18, 2026

26 people who take Epiduo and Wellbutrin together, and have interactions are studied.

Epiduo and Wellbutrin drug interactions.

What are the common drug interactions of Epiduo and Wellbutrin, by gender? *:

female:

Drug effect decreased
Dry skin
Ear pain
Erythema (redness of the skin)
Headache (pain in head)
Histoplasmosis (infection caused by breathing in spores of a fungus)
Hypoacusis (loss of hearing)
Muscle spasms (muscle contraction)
Myasthenia gravis (a chronic condition that causes muscles to tire and weaken easily)
Pruritus (severe itching of the skin)

male:

Optic neuropathy (optic nerve damage)
Therapeutic response unexpected
Muscle spasms (muscle contraction)
Weight decreased
Retinal degeneration (death of the cells of the retina)
Retinal tear
Suicidal ideation
Surgery
Constipation
Drug ineffective

What are the common drug interactions of Epiduo and Wellbutrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Optic neuropathy (optic nerve damage)
Retinal degeneration (death of the cells of the retina)
Retinal tear
Therapeutic response unexpected
Visual impairment

20-29:

Constipation
Drug ineffective
Dry eye (lack of adequate tears)
Optic neuropathy (optic nerve damage)
Therapeutic response unexpected
Eructation (release of gas from the digestive tract)
Flatulence (flatus expelled through the anus)
Muscle spasms (muscle contraction)
Glaucoma (increased fluid pressure in the eye with vision loss)
Suicidal ideation

30-39:

Periorbital disorder (gum inflammation to serious disease that results in major damage to the soft tissue and bone that support the teeth)
Eye swelling
Headache (pain in head)

40-49:

n/a

50-59:

Drug effect decreased
Dry skin
Erythema (redness of the skin)
Pruritus (severe itching of the skin)
Rash
Seborrhoea (a disease of the sebaceous glands characterized by excessive secretion of sebum)
Skin burning sensation
Skin irritation

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 21 people, 80.77%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 13 people, 50.00%
Gilles De La Tourette Syndrome (a condition that causes people to make repeated, quick movements or sounds that they cannot control): 10 people, 38.46%
Muscle Twitching: 9 people, 34.62%
Dry Eyes (lack of adequate tears): 3 people, 11.54%
Drowsiness: 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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