Epipen and Prograf drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epipen (epinephrine) and Prograf (tacrolimus). Common drug interactions include cough among females and blood pressure increased among males.

The phase IV clinical study analyzes what interactions people have when they take Epipen and Prograf. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Epipen?

Epipen has active ingredients of epinephrine. It is often used in anaphylaxis. eHealthMe is studying from 23,760 Epipen users. Check the latest studies of Epipen.

What is Prograf?

Prograf has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 42,230 Prograf users. Check the latest studies of Prograf.

On Jul, 10, 2026

81 people who take Epipen and Prograf together, and have interactions are studied.

What are the common drug interactions of Epipen and Prograf, by gender? *:

female:

Cough
Death
Dehydration (dryness resulting from the removal of water)
Depression
Drug hypersensitivity
Ear infection
Eczema infected (eczema due to bacterial infection or with bacterial infection)
Endocrine pancreatic disorder
Herpes zoster
Impaired work ability

male:

Blood pressure increased
Dizziness
Arrhythmia (irregular heartbeat)
Back pain
Cough
Drug ineffective
Gout (uric acid crystals building up in the body)
Hypertension (high blood pressure)
Hypoaesthesia (reduced sense of touch or sensation)
Hypotension (abnormally low blood pressure)

What are the common drug interactions of Epipen and Prograf, by age (0-1 to 60+)? *:

0-1:

Dehydration (dryness resulting from the removal of water)
Pyrexia (fever)
Renal failure (kidney dysfunction)
Vomiting

2-9:

Respiratory tract infection viral

10-19:

Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Dyspnoea (difficult or laboured respiration)
Reaction to drug excipients
Headache (pain in head)
Pyrexia (fever)

20-29:

Fall
Headache (pain in head)
Upper limb fracture
Wound

30-39:

Hypoaesthesia (reduced sense of touch or sensation)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Back disorder

40-49:

Dyspepsia (indigestion)
Gastric ulcer (stomach ulcer)
Hepatic cyst
Hyperhidrosis (abnormally increased sweating)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Joint injury
Loss of consciousness
Multiple allergies (allergy to multiple agents)
Pallor

50-59:

Blood pressure increased
Restlessness (not able to rest)
Accidental exposure
Cough
Heart rate increased
Injection site anaesthesia
Injection site haematoma (localized swelling filled with blood at injection site)
Injection site pallor (an unhealthy pale appearance at injection site)
Palpitations (feelings or sensations that your heart is pounding or racing)
Pyrexia (fever)

60+:

Abdominal distension
Arrhythmia (irregular heartbeat)
Infection
Influenza
Loss of consciousness
Pain
Pyrexia (fever)
Upper respiratory tract infection
Dizziness
Drug ineffective

What are the existing conditions these people have? *

Fabry's Disease (build up of a particular type of fat, called globotriaosylceramide, in the body's cells): 31 people, 38.27%
Skin Blushing/flushing (a sudden reddening of the face, neck): 11 people, 13.58%
Immunodeficiency Common Variable: 11 people, 13.58%
Lipidosis (disorder of lipid metabolism involving abnormal accumulation of lipids in the reticuloendothelial cells): 8 people, 9.88%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 8 people, 9.88%

* Approximation only. Some reports may have incomplete information.

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