Eplerenone and Morphine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Eplerenone (eplerenone) and Morphine (morphine sulfate). Common drug interactions include abdominal pain upper among females and hypotension among males.

The phase IV clinical study analyzes what interactions people have when they take Eplerenone and Morphine. It is created by eHealthMe based on reports of 98 people who take the same drugs from the FDA, and is updated regularly.

What is Eplerenone?

Eplerenone has active ingredients of eplerenone. It is often used in high blood pressure. eHealthMe is studying from 9,979 Eplerenone users. Check the latest studies of Eplerenone.

What is Morphine?

Morphine has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 182,914 Morphine users. Check the latest studies of Morphine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

98 people who take Eplerenone and Morphine together, and have interactions are studied.

Eplerenone and Morphine drug interactions.

What are the common drug interactions of Eplerenone and Morphine, by gender? *:

female:

Abdominal pain upper
Cardiorenal syndrome (kidney failure and heart failure)
Death
Disease progression
Fall
Nausea (feeling of having an urge to vomit)
Weight increased
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Abdominal infection
Abdominal pain

male:

Hypotension (abnormally low blood pressure)
Drug ineffective
Asthenia (weakness)
Blood iron decreased
Decreased appetite
Depressed mood
Dyspnoea (difficult or laboured respiration)
Fear
Feeding disorder (when children refuse to eat certain food groups)
Fluid intake reduced

What are the common drug interactions of Eplerenone and Morphine, by age (0-1 to 60+)? *:

0-1:

Hallucination (an experience involving the perception of something not present)

2-9:

n/a

10-19:

n/a

20-29:

Abdominal infection
Abdominal pain upper
Acidosis (build-up of carbon dioxide in the blood)
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Asthenia (weakness)
Blood cholesterol increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bronchopleural fistula
Cardiac failure congestive
Cardiomegaly (increased size of heart than normal)

30-39:

n/a

40-49:

Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Cardiac failure
Fluid overload (too much fluid in the blood)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Blood electrolytes decreased
Blood potassium decreased
Localised oedema (fluid retention in a particular part of the body)
Cardiac disorder
Chronic kidney disease
Disease complication

50-59:

Gastric haemorrhage (bleeding stomach)
Pneumonia
Chronic kidney disease
Death
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Axonal neuropathy (dysfunction of axon nerves)
Blood creatinine increased
Cardiac failure chronic
Cardiorenal syndrome (kidney failure and heart failure)

60+:

Hypotension (abnormally low blood pressure)
Drug ineffective
Anxiety
Asthenia (weakness)
Blood iron decreased
Depressed mood
Dyspnoea (difficult or laboured respiration)
Fear
Feeding disorder (when children refuse to eat certain food groups)
Fluid intake reduced

What are the existing conditions these people have? *

Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 21 people, 21.43%
Cardiac Failure Congestive: 19 people, 19.39%
Dyslipidaemia (abnormal amount of lipids): 19 people, 19.39%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 18 people, 18.37%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 17 people, 17.35%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 17 people, 17.35%
Dyspnea (difficult or laboured breathing): 17 people, 17.35%
Arrhythmias (irregular heartbeat): 16 people, 16.33%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 13 people, 13.27%
Nausea (feeling of having an urge to vomit): 10 people, 10.20%

* Approximation only. Some reports may have incomplete information.

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