Eplerenone and Zoledronic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Eplerenone (eplerenone) and Zoledronic (zoledronic acid). Common drug interactions include anaemia among females and myalgia among males.

The phase IV clinical study analyzes what interactions people have when they take Eplerenone and Zoledronic. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Eplerenone?

Eplerenone has active ingredients of eplerenone. It is often used in high blood pressure. eHealthMe is studying from 9,979 Eplerenone users. Check the latest studies of Eplerenone.

What is Zoledronic?

Zoledronic has active ingredients of zoledronic acid. eHealthMe is studying from 29,812 Zoledronic users. Check the latest studies of Zoledronic.



On Jul, 13, 2026

45 people who take Eplerenone and Zoledronic together, and have interactions are studied.

Eplerenone and Zoledronic drug interactions.

What are the common drug interactions of Eplerenone and Zoledronic, by gender? *:

female:

  1. Anaemia (lack of blood)
  2. Leukopenia (less number of white blood cells in blood)
  3. Thrombocytopenia (decrease of platelets in blood)
  4. Arthralgia (joint pain)
  5. Back pain
  6. Bone pain
  7. Depression
  8. Headache (pain in head)
  9. Pain in extremity

male:

  1. Myalgia (muscle pain)
  2. Vomiting
  3. Dizziness
  4. Fluid retention (an abnormal accumulation of fluid in the blood)
  5. Headache (pain in head)
  6. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
  7. Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
  8. Hypotension (abnormally low blood pressure)
  9. Influenza like illness
  10. Muscular weakness (muscle weakness)

What are the common drug interactions of Eplerenone and Zoledronic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Cardiac arrest
  2. Infusion related reaction

20-29:

  1. Pyrexia (fever)
  2. Arthralgia (joint pain)
  3. Bone pain
  4. Chills (felling of cold)
  5. Cold sweat
  6. Dehydration (dryness resulting from the removal of water)
  7. Dizziness
  8. Fluid retention (an abnormal accumulation of fluid in the blood)
  9. Headache (pain in head)
  10. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

30-39:

n/a

40-49:

n/a

50-59:

  1. Plasma cell myeloma (cancer that begins in plasma cells)

60+:

  1. Malaise (a feeling of general discomfort or uneasiness)
  2. Myalgia (muscle pain)
  3. Pain in extremity
  4. Pleural effusion (water on the lungs)
  5. Peripheral swelling
  6. Vomiting
  7. Metastases to bone (cancer spreads to bone)
  8. Arthralgia (joint pain)
  9. Back pain
  10. Bone pain

What are the existing conditions these people have? *

  1. Osteopenia (a condition where bone mineral density is lower than normal): 6 people, 13.33%
  2. Indigestion: 6 people, 13.33%
  3. Cardiomyopathy (weakening of the heart muscle): 6 people, 13.33%
  4. Multiple Myeloma (cancer of the plasma cells): 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Eplerenone and Zoledronic?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Eplerenone and Zoledronic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Eplerenone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Zoledronic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Eplerenone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zoledronic and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on eplerenone and zoledronic acid (the active ingredients of Eplerenone and Zoledronic, respectively), and Eplerenone and Zoledronic (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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