Sertraline and Rocaltrol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sertraline (sertraline hydrochloride) and Rocaltrol (calcitriol). Common drug interactions include hyperparathyroidism secondary among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Sertraline and Rocaltrol. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Sertraline?

Sertraline has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 153,304 Sertraline users. Check the latest studies of Sertraline.

What is Rocaltrol?

Rocaltrol has active ingredients of calcitriol. It is often used in hypoparathyroidism. eHealthMe is studying from 7,562 Rocaltrol users. Check the latest studies of Rocaltrol.

On Jul, 13, 2026

55 people who take Sertraline and Rocaltrol together, and have interactions are studied.

Sertraline and Rocaltrol drug interactions.

What are the common drug interactions of Sertraline and Rocaltrol, by gender? *:

female:

Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Arthralgia (joint pain)
Blood urea increased
Cardiovascular insufficiency (inadequate functioning of heart)
Dementia alzheimer's type (loss of mental ability with alzheimer's symptom)
Dry mouth
Eating disorder
Fall
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hyperlipidaemia (presence of excess lipids in the blood)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Fatigue (feeling of tiredness)
Focal segmental glomerulosclerosis (scar tissue that forms in parts of the kidney called glomeruli)
Hyperkalaemia (damage to or disease of the kidney)
Leukopenia (less number of white blood cells in blood)
Nodule (a growth of abnormal tissue)
Proteinuria (presence of protein in the urine)
Septic embolus (a type of embolism that is infected with bacteria)

What are the common drug interactions of Sertraline and Rocaltrol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anaemia (lack of blood)
Biliary cirrhosis primary (primary biliary cirrhosis (pbc) is a long-term liver disease that damages the small bile ducts in the liver. the build-up of bile damages the liver)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dysmenorrhoea (painful menstruation)
Femoral neck fracture (neck of femur bone fracture)
Leukocytosis (increased white blood cells)
Hyperlipidaemia (presence of excess lipids in the blood)
Blood cholesterol increased
Gamma-glutamyltransferase increased
Injury

50-59:

Encephalopathy (functioning of the brain is affected by some agent or condition)
Eye pain
Feeling cold
Generalised oedema (swelling all over the body)
Haemorrhage (bleeding)
Hallucination (an experience involving the perception of something not present)
Hyperhidrosis (abnormally increased sweating)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Infectious mononucleosis (infection usually caused by the epstein-barr virus)
Infusion related reaction

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Dry mouth
Eating disorder
Fall
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium)
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins)
Labyrinthitis (inflammation of the labyrinth or inner ear)
Lactose intolerance (inability to digest lactose)

What are the existing conditions these people have? *

Pain: 14 people, 25.45%
Stress And Anxiety: 11 people, 20.00%
High Blood Pressure: 10 people, 18.18%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 18.18%
Neuralgia (pain in one or more nerves): 8 people, 14.55%
Diabetes: 7 people, 12.73%
Fluid Retention (an abnormal accumulation of fluid in the blood): 7 people, 12.73%
High Blood Cholesterol: 7 people, 12.73%
Osteoporosis (bones weak and more likely to break): 6 people, 10.91%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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