Escitalopram and Epclusa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Escitalopram (escitalopram oxalate) and Epclusa (sofosbuvir; velpatasvir). Common drug interactions include vomiting among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Escitalopram and Epclusa. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Escitalopram?

Escitalopram has active ingredients of escitalopram oxalate. It is often used in depression. eHealthMe is studying from 78,080 Escitalopram users. Check the latest studies of Escitalopram.

What is Epclusa?

Epclusa has active ingredients of sofosbuvir; velpatasvir. eHealthMe is studying from 12,120 Epclusa users. Check the latest studies of Epclusa.

On Jul, 11, 2026

41 people who take Escitalopram and Epclusa together, and have interactions are studied.

Escitalopram and Epclusa drug interactions.

What are the common drug interactions of Escitalopram and Epclusa, by gender? *:

female:

Vomiting
Abdominal pain
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Death
Diarrhoea
Dizziness
Fatigue (feeling of tiredness)
Pain
Pneumonia

male:

Fatigue (feeling of tiredness)
Pancreatitis (inflammation of pancreas)
Nausea (feeling of having an urge to vomit)
Skin papilloma (a general medical term for a tumour of the skin or mucous membrane with finger-like projections)
Skin ulcer
Vomiting
Pneumonia
Abdominal discomfort
Cardiac failure
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the common drug interactions of Escitalopram and Epclusa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Pancreatitis (inflammation of pancreas)

40-49:

Abdominal pain
Dizziness
Nausea (feeling of having an urge to vomit)
Vomiting
Asterixis (flapping tremor, or liver flap)
Blood pressure systolic decreased
Chest discomfort
Decreased appetite
Depressed level of consciousness
Diarrhoea

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Asthenia (weakness)
Blood glucose increased
Bone density decreased
Disseminated tuberculosis
Emotional distress
Gait disturbance
Oedema peripheral (superficial swelling)
Osteoporosis (bones weak and more likely to break)
Pain

60+:

Pneumonia
Abdominal discomfort
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Pleuritic pain
Vomiting
Ascites (accumulation of fluid in the abdominal cavity)
Biliary dilatation
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the existing conditions these people have? *

Hepatitis C: 16 people, 39.02%

* Approximation only. Some reports may have incomplete information.

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