Esgic and Librium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Esgic (acetaminophen; butalbital; caffeine) and Librium (chlordiazepoxide hydrochloride). Common drug interactions include depression among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Esgic and Librium. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Esgic?

Esgic has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 882 Esgic users. Check the latest studies of Esgic.

What is Librium?

Librium has active ingredients of chlordiazepoxide hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 2,490 Librium users. Check the latest studies of Librium.

On Jul, 14, 2026

11 people who take Esgic and Librium together, and have interactions are studied.

What are the common drug interactions of Esgic and Librium, by gender? *:

female:

Depression
Affect lability (emotional incontinence)
Agitation (state of anxiety or nervous excitement)
Anger
Asthenia (weakness)
Bladder neck suspension
Bradycardia (abnormally slow heart action)
Confusional state
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)

male:

Drug ineffective

What are the common drug interactions of Esgic and Librium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anger
Confusional state
Dependence
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Fatigue (feeling of tiredness)
Intentional self-injury
Social avoidant behaviour (avoiding social connection a personality disorder)
Suicide attempt
Type 2 diabetes mellitus

50-59:

Agitation (state of anxiety or nervous excitement)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Neuromyopathy (disease of both muscles and nerves)
Osteoporosis (bones weak and more likely to break)
Otitis media (inflammation of the middle ear)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Sinusitis (inflammation of sinus)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Visual impairment
Bladder neck suspension

60+:

Drug ineffective

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 63.64%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 63.64%
Depression: 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

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