Esgic and Reglan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Esgic (acetaminophen; butalbital; caffeine) and Reglan (metoclopramide hydrochloride). Common drug interactions include multiple fractures among females and abdominal distension among males.

The phase IV clinical study analyzes what interactions people have when they take Esgic and Reglan. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Esgic?

Esgic has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 882 Esgic users. Check the latest studies of Esgic.

What is Reglan?

Reglan has active ingredients of metoclopramide hydrochloride. It is often used in gastroparesis. eHealthMe is studying from 29,455 Reglan users. Check the latest studies of Reglan.

On Jul, 16, 2026

18 people who take Esgic and Reglan together, and have interactions are studied.

What are the common drug interactions of Esgic and Reglan, by gender? *:

female:

Multiple fractures
Nail disorder (disease of nail)
Obesity (having too much body fat)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain
Pain in extremity
Post procedural haemorrhage (post procedural bleeding)
Pyrexia (fever)
Rectal haemorrhage (bleeding from anus)

male:

Abdominal distension
Anxiety
Irritable bowel syndrome
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nephrolithiasis (calculi in the kidneys)
Oedema peripheral (superficial swelling)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Pain
Pulmonary oedema (fluid accumulation in the lungs)
Vertigo

What are the common drug interactions of Esgic and Reglan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal distension
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Constipation
Diarrhoea
Haemoglobin decreased
Megacolon (a very dilated colon)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Post procedural haemorrhage (post procedural bleeding)
Pyrexia (fever)
Rectal haemorrhage (bleeding from anus)

30-39:

Vomiting
Anxiety
Aortic valve incompetence
Blood albumin decreased
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Depression
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Herpes simplex (herpes simplex is a common viral infection)
Irritability

40-49:

Brain neoplasm (tumour of brain)
Hypothalamo-pituitary disorder (loss of function in an endocrine gland due to failure of the pituitary gland to secrete hormones which stimulate that gland's function)
Abdominal distension
Anxiety
Arteriosclerosis (thickening and hardening of arteries)
Ascites (accumulation of fluid in the abdominal cavity)
Back pain
Cardiac disorder
Cardiomyopathy (weakening of the heart muscle)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)

50-59:

Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Glaucoma (increased fluid pressure in the eye with vision loss)
Haematoma infection (infection with collection of blood outside the blood vessels)
Homicidal ideation (thoughts about human killing another human)
Lower limb fracture
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Multiple fractures
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain in extremity

60+:

Weight increased
Pain

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 16.67%
Gastric Disorder (disease of stomach): 3 people, 16.67%
Headache (pain in head): 3 people, 16.67%
High Blood Cholesterol: 2 people, 11.11%
Depression: 2 people, 11.11%
Lambert-Eaton Syndrome (this means your immune system mistakenly targets healthy cells and tissues in the body): 2 people, 11.11%
High Blood Pressure: 2 people, 11.11%
Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 5.56%
Bladder Disorder: 1 person, 5.56%
Cardiac Disorder: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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