Eskalith and Desyrel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Eskalith (lithium carbonate) and Desyrel (trazodone hydrochloride). Common drug interactions include type 2 diabetes mellitus among females and blood creatine phosphokinase increased among males.

The phase IV clinical study analyzes what interactions people have when they take Eskalith and Desyrel. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Eskalith?

Eskalith has active ingredients of lithium carbonate. eHealthMe is studying from 1,448 Eskalith users. Check the latest studies of Eskalith.

What is Desyrel?

Desyrel has active ingredients of trazodone hydrochloride. It is often used in insomnia. eHealthMe is studying from 6,595 Desyrel users. Check the latest studies of Desyrel.

On Jul, 14, 2026

30 people who take Eskalith and Desyrel together, and have interactions are studied.

What are the common drug interactions of Eskalith and Desyrel, by gender? *:

female:

Type 2 diabetes mellitus
Blood cholesterol increased
Weight increased
Bipolar disorder (mood disorder)
Blood triglycerides increased
Glycosuria (excretion of glucose into the urine)
Hyperlipidaemia (presence of excess lipids in the blood)
Intervertebral disc protrusion (spinal disc protrusion)
Obesity (having too much body fat)
Tardive dyskinesia (a disorder that involves involuntary movements)

male:

Blood creatine phosphokinase increased
Mania (a state of abnormally elevated or irritable mood)
Hypersomnia (excessive daytime sleepiness (eds))
Hypotension (abnormally low blood pressure)
Infection
Nasopharyngitis (inflammation of the nasopharynx)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Polycythaemia (proportion of blood volume that is occupied by red blood cells increases)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)

What are the common drug interactions of Eskalith and Desyrel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood cholesterol increased
Glycosuria (excretion of glucose into the urine)
Hyperlipidaemia (presence of excess lipids in the blood)
Intervertebral disc protrusion (spinal disc protrusion)
Obesity (having too much body fat)
Type 2 diabetes mellitus
Restlessness (not able to rest)
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)

30-39:

Type 2 diabetes mellitus
Bipolar disorder (mood disorder)
Blood cholesterol increased
Blood triglycerides increased
Weight increased
Pancreatitis acute (sudden inflammation of pancreas)
Blood glucose increased
Cardiac arrest
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic retinopathy (damage to the retina caused by complications of diabetes)

40-49:

Nasopharyngitis (inflammation of the nasopharynx)
Type 2 diabetes mellitus
Mania (a state of abnormally elevated or irritable mood)
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Blood cholesterol increased
Blood creatine phosphokinase increased
Chest pain
Enuresis (repeated inability to control urination)
Haematochezia (passage of stools containing blood)
Hepatic steatosis (fatty liver disease)

50-59:

Drug level increased
Hypoglycaemia (deficiency of glucose in the bloodstream)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Nervousness
Urinary tract infection
Pain
Anxiety
Depressed level of consciousness

60+:

Blood creatine phosphokinase increased
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Head injury
Hypoaesthesia (reduced sense of touch or sensation)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Tremor (trembling or shaking movements in one or more parts of your body)
Writing impaired

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 11 people, 36.67%
Sleep Disorder: 6 people, 20.00%
Depression: 6 people, 20.00%
Stress And Anxiety: 3 people, 10.00%
Muscle Spasms (muscle contraction): 3 people, 10.00%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 6.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 6.67%
Drowsiness: 2 people, 6.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 6.67%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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