Estrace and Chantix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Estrace (estradiol) and Chantix (varenicline tartrate). Common drug interactions include anxiety among females and breast cancer metastatic among males.

The phase IV clinical study analyzes what interactions people have when they take Estrace and Chantix. It is created by eHealthMe based on reports of 95 people who take the same drugs from the FDA, and is updated regularly.

What is Estrace?

Estrace has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 16,703 Estrace users. Check the latest studies of Estrace.

What is Chantix?

Chantix has active ingredients of varenicline tartrate. It is often used in quit smoking. eHealthMe is studying from 89,889 Chantix users. Check the latest studies of Chantix.

On Jul, 08, 2026

95 people who take Estrace and Chantix together, and have interactions are studied.

What are the common drug interactions of Estrace and Chantix, by gender? *:

female:

Anxiety
Therapeutic response unexpected
Insomnia (sleeplessness)
Anger
Constipation
Fatigue (feeling of tiredness)
Headache (pain in head)
Aggression
Irritability
Emotional disorder

male:

Breast cancer metastatic
Anxiety
Depression
Suicide attempt
Anger
Irritability
Loss of consciousness

What are the common drug interactions of Estrace and Chantix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Aggression
Anger
Anxiety
Insomnia (sleeplessness)
Irritability
Nausea (feeling of having an urge to vomit)

40-49:

Abnormal dreams
Anger
Constipation
Depression
Dry mouth
Emotional disorder
Insomnia (sleeplessness)
Irritability
Memory impairment
Mood altered (changes in mood)

50-59:

Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Erythema (redness of the skin)
Faecal incontinence (a lack of control over passing stool)
Fungal infection
Gait disturbance
Gastritis (inflammation of stomach)
Hair follicle tumour benign
Headache (pain in head)
Hilar lymphadenopathy (disease of the lymph nodes due to infection)
Hot flush (sudden feelings of heat)

60+:

Nausea (feeling of having an urge to vomit)
Chronic kidney disease
Renal impairment (severely reduced kidney function)
Sleep disorder
Vomiting
Drug ineffective
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Alopecia (absence of hair from areas of the body)
Anxiety
Chest discomfort

What are the existing conditions these people have? *

High Blood Pressure: 17 people, 17.89%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 13.68%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 13 people, 13.68%
Depression: 12 people, 12.63%
Pain: 9 people, 9.47%
Muscle Spasms (muscle contraction): 8 people, 8.42%
Sleep Disorder: 8 people, 8.42%
Diabetes: 8 people, 8.42%
High Blood Cholesterol: 7 people, 7.37%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 7.37%

* Approximation only. Some reports may have incomplete information.

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