Benadryl and Ranolazine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Ranolazine (ranolazine). Common drug interactions include laceration among females and chest pain among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Ranolazine. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

What is Ranolazine?

Ranolazine has active ingredients of ranolazine. eHealthMe is studying from 9,939 Ranolazine users. Check the latest studies of Ranolazine.

On Jul, 08, 2026

33 people who take Benadryl and Ranolazine together, and have interactions are studied.

Benadryl and Ranolazine drug interactions.

What are the common drug interactions of Benadryl and Ranolazine, by gender? *:

female:

Laceration (tearing of soft body tissue)
Lipoma (a growth of fatty tissue that slowly develops just under your skin)
Muscular weakness (muscle weakness)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Myopathy toxic (a muscular disease in which the muscle fibres do not function due to toxin)
Neck pain
Oedema peripheral (superficial swelling)
Parkinson's disease
Parkinsonism (degenerative disorder of the central nervous system characterized by tremor and impaired muscular coordination)
Peripheral swelling

male:

Chest pain
Dyspnoea (difficult or laboured respiration)
Dysphagia (a condition in which swallowing is difficult or painful)
Dysphonia (speech disorder attributable to a disorder of phonation)
Fall
Headache (pain in head)
Hereditary angioedema (recurrent episodes of severe swelling)
Incontinence (lack of moderation or self-control)
Infusion related reaction
Loss of consciousness

What are the common drug interactions of Benadryl and Ranolazine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Chronic kidney disease
Fatigue (feeling of tiredness)
Flushing (the warm, red condition of human skin)
Gingival swelling (gums swelling)
Injection site bruising
Injection site pain
Swelling
Thrombosis (formation of a blood clot inside a blood vessel)
Abdominal pain upper
Decreased appetite

60+:

Chest discomfort
Chest pain
Disease recurrence
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dysphagia (a condition in which swallowing is difficult or painful)
Dysphonia (speech disorder attributable to a disorder of phonation)
Hereditary angioedema (recurrent episodes of severe swelling)
Incontinence (lack of moderation or self-control)
Infusion related reaction
Loss of consciousness

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 10 people, 30.30%
Cardiac Disorder: 6 people, 18.18%
High Blood Cholesterol: 6 people, 18.18%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 18.18%
Pain: 4 people, 12.12%
Stress And Anxiety: 4 people, 12.12%
Stable Angina (a constant chest pain): 4 people, 12.12%
Depression: 4 people, 12.12%
Diabetes: 4 people, 12.12%
High Blood Pressure: 4 people, 12.12%

* Approximation only. Some reports may have incomplete information.

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