Estraderm and Cozaar drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Estraderm (estradiol) and Cozaar (losartan potassium). Common drug interactions include breast cancer among females.
The phase IV clinical study analyzes what interactions people have when they take Estraderm and Cozaar. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.
What is Estraderm?
Estraderm has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 3,441 Estraderm users. Check the latest studies of Estraderm.
What is Cozaar?
Cozaar has active ingredients of losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 45,124 Cozaar users. Check the latest studies of Cozaar.
58 people who take Estraderm and Cozaar together, and have interactions are studied.

What are the common drug interactions of Estraderm and Cozaar, by gender? *:
female:
- Breast cancer
- Depression
- Anaemia (lack of blood)
- Breast mass
- Anxiety
- Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
- Fibromyalgia (a long-term condition which causes pain all over the body)
- Arteriosclerosis (thickening and hardening of arteries)
- Chest pain
- Pain in extremity
male:
n/a
What are the common drug interactions of Estraderm and Cozaar, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
- Alopecia (absence of hair from areas of the body)
- Blood parathyroid hormone increased
- Fluorosis (a developmental disturbance of tooth enamel due to high concentration of fluoride)
- High turnover osteopathy (potential adverse side effect of calcium (unspecified))
- Rales (an abnormal respiratory sound characterized by fine crackles)
- Skin nodule (slightly elevated lesions on or in the skin)
20-29:
n/a
30-39:
n/a
40-49:
- Alopecia (absence of hair from areas of the body)
- Arteriosclerosis (thickening and hardening of arteries)
- Arthralgia (joint pain)
- Arthritis (form of joint disorder that involves inflammation of one or more joints)
- Asthenia (weakness)
- Back pain
- Bone pain
- Breast calcifications (deposits of calcium that can be seen on a mammogram of the breast)
- Breast cancer
- Breast cyst
50-59:
- Anxiety
- Arteriosclerosis (thickening and hardening of arteries)
- Arthritis (form of joint disorder that involves inflammation of one or more joints)
- Asthenia (weakness)
- Back pain
- Breast pain
- Cervical dysplasia (abnormal changes in the cells on the surface of the cervix)
- Cervicobrachial syndrome (pain in neck and arm with changing location)
- Chronic fatigue syndrome (disorder that causes extreme fatigue)
- Dizziness
60+:
- Breast cancer
- Depression
- Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
- Chemotherapy
- Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
- Breast cyst
- Postoperative wound complication
- Anxiety
- Cluster headache (one-sided head pain with tearing)
- Fatigue (feeling of tiredness)
What are the existing conditions these people have? *
- Menopausal Symptoms: 15 people, 25.86%
- Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 15 people, 25.86%
- Menopause (end of monthly cycles in women): 14 people, 24.14%
- Diabetes: 7 people, 12.07%
- Malaria (a parasitic disease due to mosquito bite): 6 people, 10.34%
- Stress And Anxiety: 4 people, 6.90%
- High Blood Cholesterol: 4 people, 6.90%
- Depression: 4 people, 6.90%
- Pneumonia: 3 people, 5.17%
- Oedema (fluid collection in tissue): 3 people, 5.17%
* Approximation only. Some reports may have incomplete information.
Do you take Estraderm and Cozaar?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Estraderm and Cozaar:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Estraderm:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Cozaar:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Estraderm and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Cozaar and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Lai SW, Lin HF, Lin CL, Liao KF, "No association between losartan use and acute pancreatitis in hypertensive patients", Eur J Hosp Pharm, 2017 Mar .
- Lai SW, Lin HF, Lin CL, Liao KF, "No association between losartan use and acute pancreatitis in hypertensive patients", Eur J Hosp Pharm, 2017 Mar .
How the study uses the data?
The study uses data from the FDA. It is based on estradiol and losartan potassium (the active ingredients of Estraderm and Cozaar, respectively), and Estraderm and Cozaar (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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