Benadryl and Sleep disorder - a phase IV clinical study of FDA data
Summary:
Sleep disorder is reported as a side effect among people who take Benadryl (diphenhydramine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Tylenol, and have Rheumatoid arthritis.
The phase IV clinical study analyzes which people have Sleep disorder when taking Benadryl. It is created by eHealthMe based on reports of 100,139 people who have side effects when taking Benadryl from the FDA, and is updated regularly.
What is Benadryl?
Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.
What is Sleep disorder?
Sleep disorder is found to be associated with 2,107 drugs and 2,938 conditions by eHealthMe. Check the latest studies of Sleep disorder.
100,139 people reported to have side effects when taking Benadryl.
Among them, 1,001 people (1.0%) have Sleep disorder.

Among these 1,001 people:
How long have people been on Benadryl when they have Sleep disorder? *
What is the gender of people who have Sleep disorder when taking Benadryl? *
What is the age of people who have Sleep disorder when taking Benadryl? *
What are other drugs people take besides Benadryl? *
What are other side effects people have besides Sleep disorder? *
What are the existing conditions these people have? *
* Approximation only. Some reports may have incomplete information.
Do you take Benadryl and have Sleep disorder?
- Check whether Sleep disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, long term effects of, and alternative drugs to Benadryl:
- Benadryl (104,954 reports)
Sleep disorder treatments and more:
- Sleep disorder (167,338 reports)
How severe was Sleep disorder and when was it recovered:
Expand to all the drugs that have ingredients of diphenhydramine hydrochloride:
Sub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Benadryl:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all the drugs that are associated with Sleep disorder:
- Sleep disorder (2,107 drugs)
Browse all the conditions that are associated with Sleep disorder:
- Sleep disorder (2,938 conditions)
Related publications that referenced our studies
- Lin SC, Su YC, Huang YS, Lee CC, "Zolpidem increased cancer risk in patients with sleep disorder: A 3-year follow-up study", Journal of Medical Sciences, 2016 Mar .
- Lin SC, Su YC, Huang YS, Lee CC, "Zolpidem increased cancer risk in patients with sleep disorder: A 3-year follow-up study", Journal of Medical Sciences, 2016 Mar .
How the study uses the data?
The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Benadryl) and Benadryl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
Recent studies on eHealthMe:
- Garcinia Cambogia vs. Saxenda, side effect and effectiveness comparison - a second ago
- Diabetes Mellitus Inadequate Control and Blood Pressure Abnormal - 5 seconds ago
- Humira vs. Vimovo, side effect and effectiveness comparison - 18 seconds ago
- Drug interactions of Dofetilide and Esbriet - 25 seconds ago
- Drug interactions of Uloric and Invokana - 42 seconds ago
- Could Iron Dextran cause Abscess Oral? - 44 seconds ago
- Drug interactions of Glucosamine and Calcium Carbonate - 45 seconds ago
- Drug interactions of Cordarone and Bactrim - 54 seconds ago
- Drug interactions of Amlodipine Besylate and Metrogel - a minute ago
- Drug interactions of Nexavar and Lexapro - a minute ago