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Dofetilide and Esbriet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dofetilide (dofetilide) and Esbriet (pirfenidone). Common drug interactions include dyspnoea among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Dofetilide and Esbriet. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Dofetilide?

Dofetilide has active ingredients of dofetilide. eHealthMe is studying from 2,646 Dofetilide users. Check the latest studies of Dofetilide.

What is Esbriet?

Esbriet has active ingredients of pirfenidone. eHealthMe is studying from 39,858 Esbriet users. Check the latest studies of Esbriet.

On Jul, 09, 2026

27 people who take Dofetilide and Esbriet together, and have interactions are studied.

Dofetilide and Esbriet drug interactions.

What are the common drug interactions of Dofetilide and Esbriet, by gender? *:

female:

  1. Dyspnoea (difficult or laboured respiration)
  2. Idiopathic pulmonary fibrosis (chronic lung disease)
  3. Lung disorder (lung disease)
  4. Death
  5. Diarrhoea
  6. Hospitalisation
  7. Hypotension (abnormally low blood pressure)
  8. Memory impairment
  9. Vomiting

male:

  1. Diarrhoea
  2. Fall
  3. Headache (pain in head)
  4. Ligament sprain (ligament stretched)
  5. Abdominal discomfort
  6. Gastric disorder (disease of stomach)
  7. Vomiting
  8. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  9. Blood pressure decreased
  10. Head injury

What are the common drug interactions of Dofetilide and Esbriet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Diarrhoea
  2. Fall
  3. Rash
  4. Weight decreased
  5. Vomiting
  6. Dyspnoea (difficult or laboured respiration)
  7. Hypotension (abnormally low blood pressure)
  8. Idiopathic pulmonary fibrosis (chronic lung disease)
  9. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  10. Blood pressure decreased

What are the existing conditions these people have? *

  1. Idiopathic Pulmonary Fibrosis (chronic lung disease): 23 people, 85.19%
  2. Tinnitus (a ringing in the ears): 2 people, 7.41%
  3. Thyroid Diseases: 2 people, 7.41%
  4. Sleep Disorder: 2 people, 7.41%
  5. Pain: 2 people, 7.41%
  6. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

Do you take Dofetilide and Esbriet?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Dofetilide and Esbriet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Dofetilide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Esbriet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Dofetilide and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Esbriet and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on dofetilide and pirfenidone (the active ingredients of Dofetilide and Esbriet, respectively), and Dofetilide and Esbriet (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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