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Estring and Nuvigil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Estring (estradiol) and Nuvigil (armodafinil). Common drug interactions include drug ineffective among females.

The phase IV clinical study analyzes what interactions people have when they take Estring and Nuvigil. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Estring?

Estring has active ingredients of estradiol. eHealthMe is studying from 5,474 Estring users. Check the latest studies of Estring.

What is Nuvigil?

Nuvigil has active ingredients of armodafinil. It is often used in narcolepsy. eHealthMe is studying from 23,669 Nuvigil users. Check the latest studies of Nuvigil.

On Jul, 20, 2026

35 people who take Estring and Nuvigil together, and have interactions are studied.

Estring and Nuvigil drug interactions.

What are the common drug interactions of Estring and Nuvigil, by gender? *:

female:

  1. Drug ineffective
  2. Accident
  3. Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
  4. Urinary tract infection
  5. Blood pressure increased
  6. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  7. Diarrhoea
  8. Oropharyngeal pain
  9. Pain
  10. Fall

male:

n/a

What are the common drug interactions of Estring and Nuvigil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Gastric bypass
  2. Haemorrhoids (a swollen vein or group of veins in the region of the anus)
  3. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
  4. Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
  5. Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)

50-59:

n/a

60+:

  1. Accident
  2. Drug ineffective
  3. Pain
  4. Poor quality sleep
  5. Ankle fracture
  6. Arthralgia (joint pain)
  7. Fall
  8. Injury
  9. Vertigo
  10. Wrist fracture

What are the existing conditions these people have? *

  1. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 20 people, 57.14%
  2. Pain: 2 people, 5.71%
  3. Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 2 people, 5.71%
  4. Drowsiness: 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

Do you take Estring and Nuvigil?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Estring and Nuvigil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Estring:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Nuvigil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Estring and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Nuvigil and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on estradiol and armodafinil (the active ingredients of Estring and Nuvigil, respectively), and Estring and Nuvigil (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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