Estring and Tramadol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Estring (estradiol) and Tramadol (tramadol hydrochloride). Common drug interactions include fall among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Estring and Tramadol. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Estring?

Estring has active ingredients of estradiol. eHealthMe is studying from 5,474 Estring users. Check the latest studies of Estring.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,800 Tramadol users. Check the latest studies of Tramadol.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

62 people who take Estring and Tramadol together, and have interactions are studied.

What are the common drug interactions of Estring and Tramadol, by gender? *:

female:

Fall
Muscular weakness (muscle weakness)
Arthralgia (joint pain)
Dizziness
Vulvovaginal dryness
Eye inflammation
Fatigue (feeling of tiredness)
Hypoaesthesia (reduced sense of touch or sensation)
Neuralgia (pain in one or more nerves)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

male:

Diarrhoea
Nasopharyngitis (inflammation of the nasopharynx)
Platelet count decreased
Red blood cell count decreased
White blood cell count decreased

What are the common drug interactions of Estring and Tramadol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Vulvovaginal dryness
Vulvovaginal pain
Dyspareunia (painful sexual intercourse)
Mood swings (an extreme or rapid change in mood)
Vaginal haemorrhage (vaginal bleeding)
Vulvovaginal discomfort

50-59:

Vision blurred
Anxiety
Colitis (inflammation of colon)
Staphylococcal infection (an infection with staphylococcus bacteria)
Abdominal hernia
Arteriosclerosis (thickening and hardening of arteries)
Cystitis (inflammation of the wall of the bladder)
Cystocele (a condition that occurs when the tough fibrous wall between a woman's bladder and her vagina is torn by childbirth)
Depression
Dizziness

60+:

Muscle spasms (muscle contraction)
Arthralgia (joint pain)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pain in extremity
Arrhythmia (irregular heartbeat)
Blindness
Confusional state
Dementia (madness)
Dizziness
Eye disorder

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 17 people, 27.42%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 10 people, 16.13%
Vulvovaginal Dryness: 8 people, 12.90%
High Blood Cholesterol: 8 people, 12.90%
Neuropathy Peripheral (surface nerve damage): 7 people, 11.29%
High Blood Pressure: 5 people, 8.06%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 8.06%
Depression: 5 people, 8.06%
Stress And Anxiety: 4 people, 6.45%
Insomnia (sleeplessness): 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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