Estrogel and Nexium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Estrogel (estradiol) and Nexium (esomeprazole magnesium). Common drug interactions include drug ineffective among females.

The phase IV clinical study analyzes what interactions people have when they take Estrogel and Nexium. It is created by eHealthMe based on reports of 59 people who take the same drugs from the FDA, and is updated regularly.

What is Estrogel?

Estrogel has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 2,922 Estrogel users. Check the latest studies of Estrogel.

What is Nexium?

Nexium has active ingredients of esomeprazole magnesium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 245,678 Nexium users. Check the latest studies of Nexium.

On Aug, 11, 2026

59 people who take Estrogel and Nexium together, and have interactions are studied.

What are the common drug interactions of Estrogel and Nexium, by gender? *:

female:

Drug ineffective
Arthralgia (joint pain)
Fall
Nausea (feeling of having an urge to vomit)
Vertigo
Vomiting
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Cough
Injection site erythema (redness at injection site)
Malaise (a feeling of general discomfort or uneasiness)

male:

n/a

What are the common drug interactions of Estrogel and Nexium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Arthralgia (joint pain)
Fatigue (feeling of tiredness)
Anger
Asthenia (weakness)
Blood sodium decreased
Chills (felling of cold)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Concussion (short loss of normal brain function in response to a head injury)
Cough
Crying

50-59:

Kidney infection
Muscular weakness (muscle weakness)
Pain
Renal injury (kidney injury)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Road traffic accident
Visual acuity reduced (reduced clearness of vision)
Asthma
Fall
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)

60+:

Diarrhoea
Arthralgia (joint pain)
Headache (pain in head)
Herpes zoster
Hot flush (sudden feelings of heat)
Hyperhidrosis (abnormally increased sweating)
Influenza
Injection site erythema (redness at injection site)
Injection site rash
Malaise (a feeling of general discomfort or uneasiness)

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 8 people, 13.56%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 11.86%
Hypersensitivity: 7 people, 11.86%
Urinary Tract Infection: 4 people, 6.78%
Carcinoid Syndrome (syndrome includes flushing and diarrhoea, and, less frequently, heart failure and bronchoconstriction): 4 people, 6.78%
Stress And Anxiety: 3 people, 5.08%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 3 people, 5.08%
Indigestion: 3 people, 5.08%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 5.08%
Hot Flush (sudden feelings of heat): 3 people, 5.08%

* Approximation only. Some reports may have incomplete information.

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