Eupressyl and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Eupressyl (urapidil) and Methotrexate (methotrexate sodium). Common drug interactions include drug intolerance among females and atrial fibrillation among males.

The phase IV clinical study analyzes what interactions people have when they take Eupressyl and Methotrexate. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Eupressyl?

Eupressyl has active ingredients of urapidil. eHealthMe is studying from 2,825 Eupressyl users. Check the latest studies of Eupressyl.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 12, 2026

44 people who take Eupressyl and Methotrexate together, and have interactions are studied.

Eupressyl and Methotrexate drug interactions.

What are the common drug interactions of Eupressyl and Methotrexate, by gender? *:

female:

Drug intolerance (drug sensitivity)
Hypotension (abnormally low blood pressure)
Chest pain
Dysarthria (speech disorder)
Facial paralysis (loss of function of face muscle)
Visual field defect
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Inappropriate antidiuretic hormone secretion
B-cell lymphoma (blood cancer affecting b cells)
Acute respiratory distress syndrome

male:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Pancreatitis acute (sudden inflammation of pancreas)
Jaundice cholestatic
Septic shock (shock due to blood infection)
Dyspnoea (difficult or laboured respiration)
Nephropathy (damage to or disease of a kidney)
Renal impairment (severely reduced kidney function)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Ulcer haemorrhage (bleeding ulcer)
Urticaria (rash of round, red welts on the skin that itch intensely)

What are the common drug interactions of Eupressyl and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

B-cell lymphoma (blood cancer affecting b cells)

50-59:

Acute respiratory distress syndrome
Cytomegalovirus colitis (an inflammation of the colon from virus)
Cytomegalovirus oesophagitis (oesophagus infection with cytomegalo virus)
Dysuria (painful or difficult urination)
Gastric ulcer haemorrhage (bleeding ulcer of stomach)
Oral candidiasis (fungal infection of mouth)
Pneumonia
Pneumonia cytomegaloviral (cmv pneumonia is caused by a member of a group of herpes-type viruses)
Pneumonia pneumococcal (pneumococcal pneumonia is a common but serious infection and inflammation of the lungs)
Rectal haemorrhage (bleeding from anus)

60+:

Drug intolerance (drug sensitivity)
Hypotension (abnormally low blood pressure)
Jaundice cholestatic
Septic shock (shock due to blood infection)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Anaemia (lack of blood)
Asthenia (weakness)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac murmur (an heart sound in valve abnormality)
Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)

What are the existing conditions these people have? *

High Blood Pressure: 19 people, 43.18%
Depression: 15 people, 34.09%
Psoriasis (immune-mediated disease that affects the skin): 9 people, 20.45%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 9 people, 20.45%
Type 2 Diabetes: 8 people, 18.18%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 8 people, 18.18%
Transitional Cell Carcinoma (cancer tumour inner most layer of urinary system): 7 people, 15.91%
Stress And Anxiety: 7 people, 15.91%
Febrile Neutropenia (fever with reduced white blood cells): 7 people, 15.91%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 11.36%

* Approximation only. Some reports may have incomplete information.

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