Evista and Clopra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Evista (raloxifene hydrochloride) and Clopra (metoclopramide hydrochloride). Common drug interactions include pain in extremity among females and angiofibroma among males.

The phase IV clinical study analyzes what interactions people have when they take Evista and Clopra. It is created by eHealthMe based on reports of 98 people who take the same drugs from the FDA, and is updated regularly.

What is Evista?

Evista has active ingredients of raloxifene hydrochloride. It is often used in osteoporosis. eHealthMe is studying from 25,891 Evista users. Check the latest studies of Evista.

What is Clopra?

Clopra has active ingredients of metoclopramide hydrochloride. eHealthMe is studying from 81,430 Clopra users. Check the latest studies of Clopra.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

98 people who take Evista and Clopra together, and have interactions are studied.

What are the common drug interactions of Evista and Clopra, by gender? *:

female:

Pain in extremity
Anaemia (lack of blood)
Constipation
Intervertebral disc protrusion (spinal disc protrusion)
Neuralgia (pain in one or more nerves)
Oedema peripheral (superficial swelling)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Injury
Hypoaesthesia (reduced sense of touch or sensation)
Spinal osteoarthritis (joint cartilage loss in spine)

male:

Angiofibroma (small, reddish brown or even flesh-coloured, smooth, shiny, 0.1- to 0.3 cm papules present over the sides of the nose and the medial portions of the cheeks)
Anxiety
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cellulitis (infection under the skin)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Compression fracture (fracture due to pressure caused by injury)
Contusion (a type of hematoma of tissue in which capillaries)
Craniocerebral injury (injury to cranium and brain)
Cystocele (a condition that occurs when the tough fibrous wall between a woman's bladder and her vagina is torn by childbirth)

What are the common drug interactions of Evista and Clopra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal distension
Abdominal pain upper
Abscess jaw (tooth abscess or root abscess)
Actinomycosis (infection that causes sores, or abscesses)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia of chronic disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Arthralgia (joint pain)
Intervertebral disc protrusion (spinal disc protrusion)
Tooth infection
Toothache (tooth pain)
White blood cell count increased
Anxiety
Impaired healing
Injury
Oedema peripheral (superficial swelling)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

60+:

Tardive dyskinesia (a disorder that involves involuntary movements)
Vomiting
Renal artery arteriosclerosis (a thickening and hardening of renal artery)
Acidosis (build-up of carbon dioxide in the blood)
Anaemia (lack of blood)
Arthralgia (joint pain)
Bacteraemia (presence of bacteria in the blood)
Cardiac valve disease (heart valve disease)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)

What are the existing conditions these people have? *

Hypercalcaemia (elevated calcium (ca+) level in the blood): 21 people, 21.43%
Breast Cancer Metastatic: 21 people, 21.43%
Breast Cancer: 21 people, 21.43%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 9.18%
Nausea (feeling of having an urge to vomit): 8 people, 8.16%
Pain: 7 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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