Excedrin and Cyanocobalamin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Excedrin (acetaminophen; aspirin; caffeine) and Cyanocobalamin (cyanocobalamin). Common drug interactions include abdominal distension among females and uveitis among males.

The phase IV clinical study analyzes what interactions people have when they take Excedrin and Cyanocobalamin. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Cyanocobalamin?

Cyanocobalamin has active ingredients of cyanocobalamin. It is often used in vitamin b12 deficiency. eHealthMe is studying from 14,651 Cyanocobalamin users. Check the latest studies of Cyanocobalamin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

44 people who take Excedrin and Cyanocobalamin together, and have interactions are studied.

Excedrin and Cyanocobalamin drug interactions.

What are the common drug interactions of Excedrin and Cyanocobalamin, by gender? *:

female:

Abdominal distension
Inflammation
Intestinal perforation (complete penetration of the wall of the intestine)
White blood cell count increased
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Viral infection
Anxiety
Blood iron decreased
Urinary tract infection
Wheezing (a high-pitched whistling sound made while you breath)

male:

Uveitis (inflammation of the uvea)

What are the common drug interactions of Excedrin and Cyanocobalamin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Injury
Thrombosis (formation of a blood clot inside a blood vessel)
Anxiety
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Emotional distress
General physical health deterioration (weak health status)

30-39:

Fall
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Viral infection
Blood iron decreased
Urinary tract infection
Wheezing (a high-pitched whistling sound made while you breath)
Cyst (a closed sac)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Loss of consciousness
Vulval cellulitis (inflammation of skin around vagina)

40-49:

Abdominal pain upper
Anxiety
Cough
Fall
Gout (uric acid crystals building up in the body)
Joint swelling
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Oral herpes (viral infection of mouth)
Oropharyngeal pain
Stress

50-59:

Small intestinal obstruction (blockage in small intestine)
Uveitis (inflammation of the uvea)
Cystitis (inflammation of the wall of the bladder)
Herpes simplex (herpes simplex is a common viral infection)
Acute respiratory failure
Chills (felling of cold)
Fluid retention (an abnormal accumulation of fluid in the blood)
Hypotension (abnormally low blood pressure)
Injection site bruising
Iron deficiency anaemia

60+:

Abdominal distension
Abdominal pain
White blood cell count increased
Seborrhoeic dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp)
Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Abdominal tenderness

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 31.82%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 22.73%
High Blood Pressure: 8 people, 18.18%
Pain: 8 people, 18.18%
Drowsiness: 8 people, 18.18%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 7 people, 15.91%
Nausea (feeling of having an urge to vomit): 6 people, 13.64%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 11.36%
Stress And Anxiety: 5 people, 11.36%
Migraine (headache): 4 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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