Excedrin and Mestinon drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Excedrin (acetaminophen; aspirin; caffeine) and Mestinon (pyridostigmine bromide). Common drug interactions include paraesthesia among females.

The phase IV clinical study analyzes what interactions people have when they take Excedrin and Mestinon. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Mestinon?

Mestinon has active ingredients of pyridostigmine bromide. It is often used in myasthenia gravis. eHealthMe is studying from 5,948 Mestinon users. Check the latest studies of Mestinon.

On Jul, 12, 2026

17 people who take Excedrin and Mestinon together, and have interactions are studied.

Excedrin and Mestinon drug interactions.

What are the common drug interactions of Excedrin and Mestinon, by gender? *:

female:

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Abdominal pain upper
Gastric ulcer haemorrhage (bleeding ulcer of stomach)
Palpitations (feelings or sensations that your heart is pounding or racing)
Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)
Therapeutic response delayed (late preventive response)
Fatigue (feeling of tiredness)
Abdominal discomfort
Death
Depression

male:

n/a

What are the common drug interactions of Excedrin and Mestinon, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abnormal faeces (abnormal stool)
Depression
Diarrhoea
Drug dependence
Fatigue (feeling of tiredness)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hypoaesthesia (reduced sense of touch or sensation)
Lethargy (tiredness)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

50-59:

n/a

60+:

Abdominal pain upper
Asthenia (weakness)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)
Therapeutic response delayed (late preventive response)
Abdominal discomfort
Death
Fall
Gastric disorder (disease of stomach)
Pneumonia

What are the existing conditions these people have? *

Migraine (headache): 4 people, 23.53%
Lambert-Eaton Syndrome (this means your immune system mistakenly targets healthy cells and tissues in the body): 3 people, 17.65%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 1 person, 5.88%
Sinus Congestion (blockage of sinus): 1 person, 5.88%
Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 5.88%
Pain In Extremity: 1 person, 5.88%
Muscle Spasms (muscle contraction): 1 person, 5.88%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 5.88%
High Blood Pressure: 1 person, 5.88%
Hereditary Angioedema (recurrent episodes of severe swelling): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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