Intermezzo and Xyrem drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Intermezzo (zolpidem tartrate) and Xyrem (sodium oxybate). Common drug interactions include hypertension among females and lyme disease among males.

The phase IV clinical study analyzes what interactions people have when they take Intermezzo and Xyrem. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Intermezzo?

Intermezzo has active ingredients of zolpidem tartrate. eHealthMe is studying from 932 Intermezzo users. Check the latest studies of Intermezzo.

What is Xyrem?

Xyrem has active ingredients of sodium oxybate. It is often used in narcolepsy. eHealthMe is studying from 81,487 Xyrem users. Check the latest studies of Xyrem.

On Jul, 12, 2026

38 people who take Intermezzo and Xyrem together, and have interactions are studied.

What are the common drug interactions of Intermezzo and Xyrem, by gender? *:

female:

Hypertension (high blood pressure)
Weight decreased
Weight increased
Drug dependence
Heart rate increased
Renal impairment (severely reduced kidney function)
Irritable bowel syndrome
Hepatic cyst
Panic attack
Respiratory rate decreased (less breathing rate/min)

male:

Lyme disease (a bacterial infection that is spread to humans by infected ticks)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Dysarthria (speech disorder)
Mydriasis (a dilation of the pupil)
Nausea (feeling of having an urge to vomit)
Therapeutic response unexpected
Type 2 diabetes mellitus
Feeling of body temperature change
Insomnia (sleeplessness)
Night sweats (sweating in night)

What are the common drug interactions of Intermezzo and Xyrem, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Arrhythmia (irregular heartbeat)
Bradycardia (abnormally slow heart action)
Coma (state of unconsciousness lasting more than six hours)
Depression
Drug abuse
Dysarthria (speech disorder)
Mydriasis (a dilation of the pupil)
Agitation (state of anxiety or nervous excitement)
Fatigue (feeling of tiredness)
Restlessness (not able to rest)

40-49:

Nausea (feeling of having an urge to vomit)
Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
Blood potassium decreased
Dopamine dysregulation syndrome (complication of the dopaminergic treatment in parkinson's disease)
Eye colour change
Insomnia (sleeplessness)
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Neuropathy peripheral (surface nerve damage)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pelvic pain

50-59:

Feeling of body temperature change
Weight increased
Insomnia (sleeplessness)
Night sweats (sweating in night)
Depression
Heart rate increased
Hepatic cyst
Hypertension (high blood pressure)
Rash
Renal impairment (severely reduced kidney function)

60+:

Lyme disease (a bacterial infection that is spread to humans by infected ticks)

What are the existing conditions these people have? *

Sleep Disorder: 11 people, 28.95%
Insomnia (sleeplessness): 10 people, 26.32%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 21.05%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 10.53%
Drowsiness: 3 people, 7.89%

* Approximation only. Some reports may have incomplete information.

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