Excedrin and Niaspan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Excedrin (acetaminophen; aspirin; caffeine) and Niaspan (niacin). Common drug interactions include eye pain among females and flushing among males.

The phase IV clinical study analyzes what interactions people have when they take Excedrin and Niaspan. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Niaspan?

Niaspan has active ingredients of niacin. It is often used in high blood cholesterol. eHealthMe is studying from 45,453 Niaspan users. Check the latest studies of Niaspan.

On Jul, 10, 2026

57 people who take Excedrin and Niaspan together, and have interactions are studied.

What are the common drug interactions of Excedrin and Niaspan, by gender? *:

female:

Eye pain
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematochezia (passage of stools containing blood)
Haemoglobin decreased
Heart rate increased
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Influenza
Irritability

male:

Flushing (the warm, red condition of human skin)
Blood glucose increased
Asthenia (weakness)
Chills (felling of cold)
Dizziness postural
Exfoliative rash (scaly red generalized skin rash)
Facial pain
Faeces discoloured
Insomnia (sleeplessness)
Myalgia (muscle pain)

What are the common drug interactions of Excedrin and Niaspan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Flushing (the warm, red condition of human skin)

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bile duct stone
Emotional distress
General physical health deterioration (weak health status)
Injury
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Biliary colic
Cholecystitis chronic (long lasting infection of gallbladder)
Blood pressure decreased

30-39:

n/a

40-49:

Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dry mouth
Dyspepsia (indigestion)
Emotional distress
Facial pain
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematochezia (passage of stools containing blood)
Hyperhidrosis (abnormally increased sweating)
Influenza

50-59:

Arthralgia (joint pain)
Flushing (the warm, red condition of human skin)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Aortic valve incompetence
Asthenia (weakness)
Blood creatinine increased
Blood pressure increased
Breast cancer stage ii
Cardiac aneurysm (a condition that can occur after a myocardial infarction due to the inadequate resistance of the new scar tissue to the systolic pressure)
Cardiac failure congestive

60+:

Fall
Depression
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Dizziness
Injection site erythema (redness at injection site)
Injection site haematoma (localized swelling filled with blood at injection site)
Injection site induration
Injection site pain
Injection site warmth
Insomnia (sleeplessness)

What are the existing conditions these people have? *

Hyperlipidaemia (presence of excess lipids in the blood): 6 people, 10.53%
High Density Lipoprotein Decreased: 5 people, 8.77%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 7.02%
Migraine (headache): 4 people, 7.02%
Hypertriglyceridaemia (excess of triglycerides in the blood): 4 people, 7.02%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 7.02%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 7.02%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 3 people, 5.26%
Night Sweats (sweating in night): 3 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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