Excedrin and Nitroglycerin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Excedrin (acetaminophen; aspirin; caffeine) and Nitroglycerin (nitroglycerin). Common drug interactions include weight decreased among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Excedrin and Nitroglycerin. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Nitroglycerin?

Nitroglycerin has active ingredients of nitroglycerin. It is often used in chest pain. eHealthMe is studying from 52,884 Nitroglycerin users. Check the latest studies of Nitroglycerin.

On Jul, 16, 2026

55 people who take Excedrin and Nitroglycerin together, and have interactions are studied.

Excedrin and Nitroglycerin drug interactions.

What are the common drug interactions of Excedrin and Nitroglycerin, by gender? *:

female:

Weight decreased
Chronic kidney disease
Drug ineffective
Hepatic failure (liver failure)
Memory impairment
Nephrogenic anaemia (anaemia due to kidney disease)
Psoriasis (immune-mediated disease that affects the skin)
Renal failure acute (rapid kidney dysfunction)
Alanine aminotransferase increased
Albumin globulin ratio increased

male:

Cardiac failure congestive
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Gout (uric acid crystals building up in the body)
Insomnia (sleeplessness)
Lung neoplasm malignant (cancer tumour of lung)
Overdose
Uveitis (inflammation of the uvea)
Anxiety
Chronic kidney disease
Concussion (short loss of normal brain function in response to a head injury)

What are the common drug interactions of Excedrin and Nitroglycerin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pulmonary embolism (blockage of the main artery of the lung)
Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Back pain
Difficulty in micturition (difficulty to urinate)
Dyspnoea (difficult or laboured respiration)

50-59:

Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously)
Presyncope
Psoriasis (immune-mediated disease that affects the skin)
Sensory disturbance (sense disturbance)
Tooth infection
Visual impairment
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Death
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Uveitis (inflammation of the uvea)

60+:

Blood calcium decreased
Mobility decreased (ability to move is reduced)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Sedation
Cardiac failure congestive
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Acute myocardial infarction (acute heart attack)
Asthenia (weakness)
Cardiac disorder
Faeces discoloured

What are the existing conditions these people have? *

High Blood Pressure: 10 people, 18.18%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 18.18%
Pain: 10 people, 18.18%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 18.18%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 9 people, 16.36%
Depression: 7 people, 12.73%
High Blood Cholesterol: 7 people, 12.73%
Insomnia (sleeplessness): 7 people, 12.73%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 10.91%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 5 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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