Zide and Implanon drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zide (hydrochlorothiazide) and Implanon (etonogestrel). Common drug interactions include angina pectoris among females and bursitis among males.

The phase IV clinical study analyzes what interactions people have when they take Zide and Implanon. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Implanon?

Implanon has active ingredients of etonogestrel. It is often used in birth control. eHealthMe is studying from 12,479 Implanon users. Check the latest studies of Implanon.

On Jul, 16, 2026

24 people who take Zide and Implanon together, and have interactions are studied.

What are the common drug interactions of Zide and Implanon, by gender? *:

female:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Diplopia (double vision)
Dysarthria (speech disorder)
Left atrial hypertrophy (enlarged left atrial a heart camber)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Acne (skin problems that cause pimples)
Adverse event
Agitation (state of anxiety or nervous excitement)
Anal abscess

male:

Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Maternal exposure during pregnancy (use of substance during pregnancy)
Pregnancy with implant contraceptive
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)

What are the common drug interactions of Zide and Implanon, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Medical device complication
Menstruation irregular

20-29:

Vertigo positional
Affective disorder (mental disorder)
Injury
Acne (skin problems that cause pimples)
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Anal abscess
Back pain
Decreased appetite
Diarrhoea
Dizziness

30-39:

Weight increased
Agitation (state of anxiety or nervous excitement)
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Crying
Device dislocation
Drug exposure during pregnancy
Medical device complication
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Psychotic disorder

40-49:

Weight increased
Menstruation delayed (late menstruation cycle)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Diplopia (double vision)
Dysarthria (speech disorder)
Left atrial hypertrophy (enlarged left atrial a heart camber)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)

50-59:

n/a

60+:

Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Maternal exposure during pregnancy (use of substance during pregnancy)
Pregnancy with implant contraceptive
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)

What are the existing conditions these people have? *

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 8 people, 33.33%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 29.17%
Tuberous Sclerosis (a rare genetic disease that causes benign tumours to grow in the brain and other organs): 4 people, 16.67%
Oedema (fluid collection in tissue): 3 people, 12.50%
Lymphangioleiomyomatosis (a rare lung condition that affects a certain type of muscle cell and only occurs in women): 3 people, 12.50%
Hypotension (abnormally low blood pressure): 3 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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