Excedrin and Serevent drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Excedrin (acetaminophen; aspirin; caffeine) and Serevent (salmeterol xinafoate). Common drug interactions include drug ineffective among females and chest pain among males.

The phase IV clinical study analyzes what interactions people have when they take Excedrin and Serevent. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Serevent?

Serevent has active ingredients of salmeterol xinafoate. It is often used in asthma. eHealthMe is studying from 15,586 Serevent users. Check the latest studies of Serevent.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

19 people who take Excedrin and Serevent together, and have interactions are studied.

Excedrin and Serevent drug interactions.

What are the common drug interactions of Excedrin and Serevent, by gender? *:

female:

Drug ineffective
Pain in extremity
Dental fistula
Fistula discharge (discharge from abnormal passage of structure/organ)
Tooth infection
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Drug hypersensitivity
Dry mouth
Emotional disorder
Insomnia (sleeplessness)

male:

Chest pain
Drug ineffective
Blood pressure systolic increased
Chest tightness
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Deafness
Malaise (a feeling of general discomfort or uneasiness)
Therapeutic response unexpected
Vertigo

What are the common drug interactions of Excedrin and Serevent, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Emotional disorder
Memory impairment

50-59:

Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Rash pruritic (redness with itching)
Vertigo
Weight increased
Chest pain
Drug ineffective
Blood pressure systolic increased
Chest tightness
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)

60+:

Dental fistula
Fistula discharge (discharge from abnormal passage of structure/organ)
Tooth infection

What are the existing conditions these people have? *

Tremor (trembling or shaking movements in one or more parts of your body): 6 people, 31.58%
Infection: 6 people, 31.58%
Cough: 6 people, 31.58%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 31.58%
High Blood Pressure: 6 people, 31.58%
Hyperlipidaemia (presence of excess lipids in the blood): 6 people, 31.58%
Hypersensitivity: 6 people, 31.58%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 31.58%
Rashes (redness): 6 people, 31.58%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 6 people, 31.58%

* Approximation only. Some reports may have incomplete information.

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