Excedrin and Tylenol w/ codeine no. 3 drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Excedrin (acetaminophen; aspirin; caffeine) and Tylenol w/ codeine no. 3 (acetaminophen; codeine phosphate). Common drug interactions include renal failure among females and delirium among males.

The phase IV clinical study analyzes what interactions people have when they take Excedrin and Tylenol w/ codeine no. 3. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Tylenol w/ codeine no. 3?

Tylenol w/ codeine no. 3 has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 4,920 Tylenol w/ codeine no. 3 users. Check the latest studies of Tylenol w/ codeine no. 3.

On Aug, 06, 2026

12 people who take Excedrin and Tylenol w/ codeine no. 3 together, and have interactions are studied.

Excedrin and Tylenol w/ codeine no. 3 drug interactions.

What are the common drug interactions of Excedrin and Tylenol W/ Codeine No. 3, by gender? *:

female:

Renal failure (kidney dysfunction)
Weakness
Abscess (pus)
Acute circulatory failure (shock)
Aggression
Blood chloride decreased
Blood glucose decreased
Blood glucose increased
Coma (state of unconsciousness lasting more than six hours)
Dehydration (dryness resulting from the removal of water)

male:

Delirium (wild excitement)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Duodenal ulcer haemorrhage (bleeding duodenal ulcer)
Faeces discoloured
Fracture
Gastric ulcer haemorrhage (bleeding ulcer of stomach)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gun shot wound
Haematemesis (vomiting of blood)
Haematocrit decreased

What are the common drug interactions of Excedrin and Tylenol W/ Codeine No. 3, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Pyelonephritis (inflammation of kidney caused by bacteria)

30-39:

n/a

40-49:

n/a

50-59:

Crush injury (compression of extremities or other parts of the body that causes muscle swelling and/or neurological disturbances)
Fracture
Gun shot wound
Head injury
Injury
Nerve injury

60+:

Delirium (wild excitement)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Acute circulatory failure (shock)
Aggression
Blood chloride decreased
Blood glucose decreased
Coma (state of unconsciousness lasting more than six hours)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Drug ineffective

What are the existing conditions these people have? *

Joint Pain: 4 people, 33.33%
Back Pain: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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