Exidine and Actigall drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Exidine (chlorhexidine gluconate) and Actigall (ursodiol). Common drug interactions include occult blood positive among females and cellulitis among males.

The phase IV clinical study analyzes what interactions people have when they take Exidine and Actigall. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Exidine?

Exidine has active ingredients of chlorhexidine gluconate. eHealthMe is studying from 17,299 Exidine users. Check the latest studies of Exidine.

What is Actigall?

Actigall has active ingredients of ursodiol. It is often used in gallstones. eHealthMe is studying from 2,162 Actigall users. Check the latest studies of Actigall.

On Jul, 26, 2026

17 people who take Exidine and Actigall together, and have interactions are studied.

What are the common drug interactions of Exidine and Actigall, by gender? *:

female:

Occult blood positive
Oedema (fluid collection in tissue)
Oedema peripheral (superficial swelling)
Oxygen consumption increased
Pain in extremity
Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose)
Rhonchi (abnormal breath sounds)
Somnolence (a state of near-sleep, a strong desire for sleep)

male:

Cellulitis (infection under the skin)
Acute graft versus host disease in liver (acute complication in liver following an allogeneic tissue/blood transplant)
Haematocrit decreased
Lymphocyte count increased
Mean cell haemoglobin increased (more than normal haemoglobin per red blood cell in a sample of blood)
Mean cell volume increased (more than normal average red blood cell volume)
Mean platelet volume increased (more than normal average size of platelet cells in blood)
Neutropenia (an abnormally low number of neutrophils)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Platelet count decreased

What are the common drug interactions of Exidine and Actigall, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Lymphocyte count increased
Mean cell haemoglobin increased (more than normal haemoglobin per red blood cell in a sample of blood)
Mean cell volume increased (more than normal average red blood cell volume)
Mean platelet volume increased (more than normal average size of platelet cells in blood)
Neutropenia (an abnormally low number of neutrophils)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Platelet count decreased
Rash
Red blood cell count decreased
Renal failure acute (rapid kidney dysfunction)

20-29:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)

30-39:

Acute respiratory failure
Cholangitis sclerosing (infection and obstruction of bile duct)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic failure (liver failure)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Pneumonia bacterial (pneumonia associated with bacterial infection)
Septic shock (shock due to blood infection)

40-49:

Abdominal pain
Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)
Gastric ulcer (stomach ulcer)
Gastrointestinal erosion (gradual destruction of gastrointestinal tract because of the inflamed mucous membrane lining the stomach)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrointestinal mucosal disorder (disorder of gastrointestinal lining mucous membranes)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hypervolaemia (abnormally increased volume of blood)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

50-59:

n/a

60+:

Death

What are the existing conditions these people have? *

Oedema Peripheral (superficial swelling): 5 people, 29.41%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 5 people, 29.41%
Thrombosis (formation of a blood clot inside a blood vessel): 4 people, 23.53%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 4 people, 23.53%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 17.65%
B-Cell Type Acute Leukaemia (cancer of the white blood cells): 3 people, 17.65%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 5.88%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 1 person, 5.88%
Itching: 1 person, 5.88%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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