Exjade and Glucophage drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Exjade (deferasirox) and Glucophage (metformin hydrochloride). Common drug interactions include nausea among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Exjade and Glucophage. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Exjade?

Exjade has active ingredients of deferasirox. It is often used in iron overload. eHealthMe is studying from 29,456 Exjade users. Check the latest studies of Exjade.

What is Glucophage?

Glucophage has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 60,851 Glucophage users. Check the latest studies of Glucophage.

On Jul, 14, 2026

62 people who take Exjade and Glucophage together, and have interactions are studied.

Exjade and Glucophage drug interactions.

What are the common drug interactions of Exjade and Glucophage, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Urticaria (rash of round, red welts on the skin that itch intensely)
Muscular weakness (muscle weakness)
Myalgia (muscle pain)
Asthenia (weakness)
Circulatory collapse
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Escherichia sepsis (bacterial infection by escherichia coli)

male:

Pyrexia (fever)
Death
Neutropenia (an abnormally low number of neutrophils)
Serum ferritin increased
Back pain
Splenomegaly (enlargement of spleen)
Anaemia (lack of blood)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)

What are the common drug interactions of Exjade and Glucophage, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Back pain
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Haemoglobin decreased
Pallor
Platelet count increased
Renal injury (kidney injury)
Serum ferritin increased
White blood cell count increased

20-29:

n/a

30-39:

Death
Abdominal pain
Anxiety
Back pain
Blood alkaline phosphatase increased
Blood glucose increased
Blood urea increased
Diarrhoea
Nausea (feeling of having an urge to vomit)
Nervousness

40-49:

Acute leukaemia (blood cancer)
Rash
Asthenia (weakness)
Death
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Fatigue (feeling of tiredness)
Iron binding capacity total decreased
Lung disorder (lung disease)
Serum ferritin increased

50-59:

Hepatitis (inflammation of the liver)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Peripheral coldness
Pyrexia (fever)
Splenomegaly (enlargement of spleen)
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups)
Muscular weakness (muscle weakness)
Myalgia (muscle pain)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

60+:

Pyrexia (fever)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Escherichia sepsis (bacterial infection by escherichia coli)
Headache (pain in head)
Pneumonia
Urticaria (rash of round, red welts on the skin that itch intensely)
Cellulitis (infection under the skin)
Circulatory collapse
Disseminated intravascular coagulation (systemic activation of blood coagulation)

What are the existing conditions these people have? *

Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 20 people, 32.26%
High Blood Pressure: 6 people, 9.68%
Haemosiderosis (general increase in tissue iron stores without associated tissue damage): 6 people, 9.68%
Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 5 people, 8.06%

* Approximation only. Some reports may have incomplete information.

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