Exjade and Ultram drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Exjade (deferasirox) and Ultram (tramadol hydrochloride). Common drug interactions include tinnitus among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Exjade and Ultram. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Exjade?

Exjade has active ingredients of deferasirox. It is often used in iron overload. eHealthMe is studying from 29,456 Exjade users. Check the latest studies of Exjade.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

On Jul, 15, 2026

38 people who take Exjade and Ultram together, and have interactions are studied.

What are the common drug interactions of Exjade and Ultram, by gender? *:

female:

Tinnitus (a ringing in the ears)
Unresponsive to stimuli
Urinary bladder haemorrhage (urinary bladder bleeding)
Blood bilirubin increased
Haemorrhage urinary tract (bleeding from uterine)
Transaminases increased
Vomiting
Aspartate aminotransferase increased
Blood calcium decreased
Bone loss

male:

Abdominal pain
Cough
Wheezing (a high-pitched whistling sound made while you breath)
Blood bilirubin increased
Bone marrow failure
Death
Eye irritation
Gastrointestinal carcinoma (cancer of stomach or intestine)
Hepatic failure (liver failure)
Metastatic neoplasm (spreadable cancer tumour)

What are the common drug interactions of Exjade and Ultram, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Bone loss
Cerebral sarcoidosis (small areas of inflammation in brain)
Hepatic enzyme increased
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Ill-defined disorder
Multiple fractures
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)

40-49:

Nausea (feeling of having an urge to vomit)
Salivary hypersecretion (excess saliva secretion)
Deafness neurosensory
Tinnitus (a ringing in the ears)
Blood bilirubin increased
Bone marrow failure
Hepatic failure (liver failure)
Thrombocytopenia (decrease of platelets in blood)
Aspartate aminotransferase increased
Blood calcium decreased

50-59:

Rash generalised (rash on most of body parts)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)

60+:

Diarrhoea
Visual impairment
Fatigue (feeling of tiredness)
Influenza
Splenomegaly (enlargement of spleen)
Thrombocytopenia (decrease of platelets in blood)
Abdominal pain
Acute respiratory failure
Blood glucose increased
Blood urea increased

What are the existing conditions these people have? *

Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 12 people, 31.58%
Serum Ferritin Increased: 4 people, 10.53%
Nausea (feeling of having an urge to vomit): 4 people, 10.53%
Urinary Tract Infection: 3 people, 7.89%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 7.89%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 3 people, 7.89%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 7.89%
Depression: 3 people, 7.89%
Tumor: 3 people, 7.89%
Haemochromatosis (body to absorb more iron than usual from food): 3 people, 7.89%

* Approximation only. Some reports may have incomplete information.

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