Febuxostat and Nesina drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Febuxostat (febuxostat) and Nesina (alogliptin benzoate). Common drug interactions include cardiac failure among females and pulmonary arterial hypertension among males.

The phase IV clinical study analyzes what interactions people have when they take Febuxostat and Nesina. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Febuxostat?

Febuxostat has active ingredients of febuxostat. eHealthMe is studying from 9,693 Febuxostat users. Check the latest studies of Febuxostat.

What is Nesina?

Nesina has active ingredients of alogliptin benzoate. eHealthMe is studying from 2,297 Nesina users. Check the latest studies of Nesina.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

21 people who take Febuxostat and Nesina together, and have interactions are studied.

Febuxostat and Nesina drug interactions.

What are the common drug interactions of Febuxostat and Nesina, by gender? *:

female:

Cardiac failure
Lactic acidosis (low ph in body tissues)
Anaemia (lack of blood)
Blood pressure decreased
Brain natriuretic peptide increased
Cardiac failure chronic
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypertension (high blood pressure)
Nasopharyngitis (inflammation of the nasopharynx)
Pulmonary hypertension (increase in blood pressure in the lung artery)

male:

Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Fall
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Drug eruption (adverse drug reaction of the skin)
Feeding disorder (when children refuse to eat certain food groups)
Gastroenteritis norovirus (inflammation of stomach and intestine caused by norovirus infection)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Haemothorax (collection of blood in the pleural space (the space between the lungs and the walls of the chest))
Headache (pain in head)
Hyperthyroidism (over activity of the thyroid gland)

What are the common drug interactions of Febuxostat and Nesina, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Death

50-59:

Nausea (feeling of having an urge to vomit)
Toxic encephalopathy (a degenerative neurologic disorder caused by exposure to toxic substances)

60+:

Lactic acidosis (low ph in body tissues)
Cardiac failure
Hypertension (high blood pressure)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Small intestine ulcer
Vomiting
Rash
Abdominal discomfort
Adrenocortical insufficiency acute (suddenly adrenal glands do not produce adequate amounts of steroid hormones)
Cerebral artery embolism (sudden blocking of an artery by a clot or foreign material)

What are the existing conditions these people have? *

Diabetes: 12 people, 57.14%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 10 people, 47.62%
High Blood Pressure: 7 people, 33.33%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 19.05%
Nausea And Vomiting: 4 people, 19.05%
Nausea (feeling of having an urge to vomit): 4 people, 19.05%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 4 people, 19.05%
Constipation: 4 people, 19.05%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 14.29%
Type 2 Diabetes: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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