Keflex and Feldene drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Keflex (cephalexin) and Feldene (piroxicam). Common drug interactions include migraine among females and abdominal pain upper among males.

The phase IV clinical study analyzes what interactions people have when they take Keflex and Feldene. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Keflex?

Keflex has active ingredients of cephalexin. It is often used in infection. eHealthMe is studying from 15,843 Keflex users. Check the latest studies of Keflex.

What is Feldene?

Feldene has active ingredients of piroxicam. It is often used in arthritis. eHealthMe is studying from 3,913 Feldene users. Check the latest studies of Feldene.

On Jan, 26, 2026

37 people who take Keflex and Feldene together, and have interactions are studied.

What are the common drug interactions of Keflex and Feldene, by gender? *:

female:

Migraine (headache)
Pruritus allergic (severe allergic itching of the skin)
Septic shock (shock due to blood infection)
Type 1 diabetes mellitus
Abdominal pain upper
Abdominal tenderness
Anuria (failure of the kidneys to produce urine)
Application site erythema (redness of the skin at application site)
Application site irritation
Application site pain

male:

Abdominal pain upper
Abscess (pus)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive
Cardiomegaly (increased size of heart than normal)
Cardiomyopathy (weakening of the heart muscle)
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Decreased interest

What are the common drug interactions of Keflex and Feldene, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypoxia (low oxygen in tissues)
Injury
Intermittent claudication
Interstitial lung disease
Intervertebral disc protrusion (spinal disc protrusion)
Intervertebral disc space narrowing (spinal disc space narrowing)
Joint effusion (presence of extra fluid in joint covering)
Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart)
Ligament disorder (disease of ligament)

30-39:

n/a

40-49:

n/a

50-59:

Abdominal tenderness
Anuria (failure of the kidneys to produce urine)
Back pain
Blood creatinine increased
Blood lactate dehydrogenase increased
Body temperature increased
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diarrhoea
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Disseminated intravascular coagulation (systemic activation of blood coagulation)

60+:

Drug hypersensitivity
Arthritis bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection)
Erythema (redness of the skin)
Joint abscess (pus in joints due to infection)
Pruritus (severe itching of the skin)
Rash
Streptococcal abscess (pus due to streptococcus bacteria)
Streptococcal infection
Pruritus allergic (severe allergic itching of the skin)
Septic shock (shock due to blood infection)

What are the existing conditions these people have? *

Bone Disorder: 15 people, 40.54%
Multiple Myeloma (cancer of the plasma cells): 10 people, 27.03%
Stress And Anxiety: 2 people, 5.41%
Sleep Disorder: 2 people, 5.41%
Post-Traumatic Stress Disorder: 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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