Femring and Premarin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Femring (estradiol acetate) and Premarin (estrogens, conjugated). Common drug interactions include chronic kidney disease among females.

The phase IV clinical study analyzes what interactions people have when they take Femring and Premarin. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Femring?

Femring has active ingredients of estradiol acetate. It is often used in menopause. eHealthMe is studying from 721 Femring users. Check the latest studies of Femring.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

On Jul, 15, 2026

15 people who take Femring and Premarin together, and have interactions are studied.

What are the common drug interactions of Femring and Premarin, by gender? *:

female:

Chronic kidney disease
Breast cancer
Syncope (loss of consciousness with an inability to maintain postural tone)
Vaginal infection
Vaginitis bacterial (inflammation of the vagina caused by bacterial infection)
Vulvovaginal dryness
Vulvovaginal mycotic infection (vulvovaginal fungal infection)
Fall
Fungal infection
Humerus fracture (injury to the upper arm bone)

male:

n/a

What are the common drug interactions of Femring and Premarin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chest pain
Drug ineffective
Hot flush (sudden feelings of heat)
Medical device complication
Night sweats (sweating in night)
Palpitations (feelings or sensations that your heart is pounding or racing)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Syncope (loss of consciousness with an inability to maintain postural tone)
Vaginitis bacterial (inflammation of the vagina caused by bacterial infection)
Vulvovaginal dryness

40-49:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
High density lipoprotein decreased
Low density lipoprotein increased (cholesterol increased in blood)
Oedema peripheral (superficial swelling)
Pain in extremity
Thrombosis (formation of a blood clot inside a blood vessel)

50-59:

n/a

60+:

Fall
Fungal infection
Vaginal infection
Humerus fracture (injury to the upper arm bone)
Breast cancer
Dyspareunia (painful sexual intercourse)
Hyperkeratosis (thickening of the outer layer of the skin)
Medical device complication
Post procedural complication
Rectocele (a bulging of the front wall of the rectum into the back wall of the vagina)

What are the existing conditions these people have? *

Menopausal Symptoms: 4 people, 26.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 20.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 20.00%
Vulvovaginal Dryness: 2 people, 13.33%
Weight Decreased: 1 person, 6.67%
High Blood Pressure: 1 person, 6.67%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 1 person, 6.67%
Genital Herpes (herpes infection of genital): 1 person, 6.67%
Headache (pain in head): 1 person, 6.67%
Heart Rate Irregular: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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