Fentanyl and Accutane drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fentanyl (fentanyl citrate) and Accutane (isotretinoin). Common drug interactions include nausea among females and inflammatory bowel disease among males.

The phase IV clinical study analyzes what interactions people have when they take Fentanyl and Accutane. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

What is Accutane?

Accutane has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 35,221 Accutane users. Check the latest studies of Accutane.

On Aug, 10, 2026

19 people who take Fentanyl and Accutane together, and have interactions are studied.

Fentanyl and Accutane drug interactions.

What are the common drug interactions of Fentanyl and Accutane, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Blood cholesterol increased
Blood triglycerides increased
Dyshidrotic eczema (skin condition in which blisters develop on the soles of your feet and/or the palms of hands)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Furuncle (infection of the hair follicle)
Hyperkeratosis (thickening of the outer layer of the skin)
Hypoaesthesia (reduced sense of touch or sensation)
Lip dry
Skin papilloma (a general medical term for a tumour of the skin or mucous membrane with finger-like projections)

male:

Inflammatory bowel disease
Colitis ulcerative (inflammation of colon with ulcer)
Overdose
Suicidal ideation
Arthralgia (joint pain)
Blood cholesterol increased
Confusional state
Decreased interest
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
General physical health deterioration (weak health status)

What are the common drug interactions of Fentanyl and Accutane, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Colitis (inflammation of colon)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Hypertransaminasaemia
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Pyrexia (fever)

10-19:

Anxiety
Colitis ulcerative (inflammation of colon with ulcer)
Inflammatory bowel disease
Abdominal pain
Cyst (a closed sac)
Otorrhoea (discharge from the ear)
Sinusitis (inflammation of sinus)
Bipolar disorder (mood disorder)
Blood cholesterol increased
Cardiac arrest

20-29:

Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Inflammatory bowel disease
Irritable bowel syndrome
Stress
Eye pain
Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Neck pain
Abdominal pain
Iron deficiency anaemia

30-39:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Injury

40-49:

Colitis ulcerative (inflammation of colon with ulcer)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Inflammatory bowel disease
Injury
Irritable bowel syndrome

50-59:

Colitis ulcerative (inflammation of colon with ulcer)
Depression
Headache (pain in head)
Inflammatory bowel disease
Irritable bowel syndrome
Monoplegia (a paralysis of a single limb)
Overdose
Respiratory depression (respiration has a rate below 12 breaths)
Somnolence (a state of near-sleep, a strong desire for sleep)
Suicidal ideation

60+:

Depression
Inflammatory bowel disease
Panic attack
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Alanine aminotransferase increased
Arthralgia (joint pain)
Aspartate aminotransferase increased
Blood cholesterol increased
Cardiac valve disease (heart valve disease)
Colitis (inflammation of colon)

What are the existing conditions these people have? *

Depression: 4 people, 21.05%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 10.53%
Stress And Anxiety: 1 person, 5.26%
Osteoporosis (bones weak and more likely to break): 1 person, 5.26%
Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 1 person, 5.26%
Multiple Myeloma (cancer of the plasma cells): 1 person, 5.26%
Metastases To Bone (cancer spreads to bone): 1 person, 5.26%
Insomnia (sleeplessness): 1 person, 5.26%
Headache (pain in head): 1 person, 5.26%
General Anaesthesia: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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