Fentanyl and Zyloprim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fentanyl (fentanyl citrate) and Zyloprim (allopurinol). Common drug interactions include altered state of consciousness among females and acute respiratory distress syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Fentanyl and Zyloprim. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

What is Zyloprim?

Zyloprim has active ingredients of allopurinol. It is often used in gout. eHealthMe is studying from 5,638 Zyloprim users. Check the latest studies of Zyloprim.

On Jul, 26, 2026

55 people who take Fentanyl and Zyloprim together, and have interactions are studied.

Fentanyl and Zyloprim drug interactions.

What are the common drug interactions of Fentanyl and Zyloprim, by gender? *:

female:

Altered state of consciousness (altered state of mind)
Anaemia megaloblastic (disorder of abnormally large red blood cells)
Anxiety
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Blood alkaline phosphatase increased
Blood creatinine increased
Bone marrow failure
Breast pain

male:

Acute respiratory distress syndrome
Pneumonia
Death
Glomerular filtration rate decreased
Organising pneumonia (pathologically by the presence in the distal air spaces of buds of granulation tissue)
Thrombocytopenia (decrease of platelets in blood)
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Cardiac failure chronic
Chronic kidney disease
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Fentanyl and Zyloprim, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Alanine aminotransferase increased
Anaemia (lack of blood)
Bone pain
Constipation
Febrile neutropenia (fever with reduced white blood cells)
Hypotension (abnormally low blood pressure)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Platelet count decreased
Proctalgia (pain in the rectum)
Pyrexia (fever)

10-19:

n/a

20-29:

Chronic kidney disease
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

30-39:

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Blood cortisol increased
Ileal ulcer
Nausea (feeling of having an urge to vomit)
Rectal haemorrhage (bleeding from anus)
Vomiting

40-49:

Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Arthralgia (joint pain)
Blood pressure increased
Migraine (headache)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pain in extremity
Irritability
Drug hypersensitivity

50-59:

Unresponsive to stimuli
Chest pain
Pneumonia
Pneumonia respiratory syncytial viral (respiratory syncytial virus (rsv) is a very common virus that leads to mild, cold-like symptoms in adults and older healthy children)
Organising pneumonia (pathologically by the presence in the distal air spaces of buds of granulation tissue)
Drug ineffective
Plasma cell myeloma (cancer that begins in plasma cells)
Confusional state
Death
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

60+:

Acute respiratory distress syndrome
Hypoxia (low oxygen in tissues)
Acute respiratory failure
Cytokine storm (over-protective immune response that can actually be fatal)
Glomerular filtration rate decreased
Anaemia (lack of blood)
Anaemia megaloblastic (disorder of abnormally large red blood cells)
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bone marrow failure

What are the existing conditions these people have? *

Constipation: 8 people, 14.55%
Nausea (feeling of having an urge to vomit): 8 people, 14.55%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 14.55%
Multiple Myeloma (cancer of the plasma cells): 7 people, 12.73%
High Blood Pressure: 6 people, 10.91%
Insomnia (sleeplessness): 6 people, 10.91%
Stress And Anxiety: 6 people, 10.91%
Type 2 Diabetes: 5 people, 9.09%
Sleep Disorder: 5 people, 9.09%
Osteoporosis (bones weak and more likely to break): 4 people, 7.27%

* Approximation only. Some reports may have incomplete information.

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