Bactrim and Prohance drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bactrim (sulfamethoxazole; trimethoprim) and Prohance (gadoteridol). Common drug interactions include oedema among females and nephrogenic systemic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Bactrim and Prohance. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

What is Prohance?

Prohance has active ingredients of gadoteridol. eHealthMe is studying from 3,734 Prohance users. Check the latest studies of Prohance.

On Jul, 26, 2026

42 people who take Bactrim and Prohance together, and have interactions are studied.

What are the common drug interactions of Bactrim and Prohance, by gender? *:

female:

Oedema (fluid collection in tissue)
Rash papular (redness with papule)
Skin plaque (red, scaly patches to appear on the skin)
Skin ulcer
Muscle fatigue (a condition in which muscles cannot exert their normal force)
Oedema peripheral (superficial swelling)
Skin discolouration (change of skin colour)
Skin disorder (skin disease)
Skin lesion
Neuralgia (pain in one or more nerves)

male:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Skin induration (an abnormally hard spot or area on the skin)
Skin hypertrophy (skin cells enlarges)
Arthralgia (joint pain)
Joint range of motion decreased (disease of joint movement)
Deformity (disfigurement)
Scar
Skin fibrosis (fibrous tissue formation on skin)
Joint stiffness
Metaplasia (change in the type of adult cells in a tissue to a form abnormal for that tissue)

What are the common drug interactions of Bactrim and Prohance, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Cardiac arrest
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Metaplasia (change in the type of adult cells in a tissue to a form abnormal for that tissue)
Mobility decreased (ability to move is reduced)
Myocardial fibrosis (a condition in which the heart's muscle cells are impaired)
Pain in extremity
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Skin induration (an abnormally hard spot or area on the skin)
Skin tightness

20-29:

n/a

30-39:

n/a

40-49:

Mobility decreased (ability to move is reduced)
Myosclerosis (hardening of muscle tissue)
Neuralgia (pain in one or more nerves)
Oedema (fluid collection in tissue)
Pain in extremity
Skin plaque (red, scaly patches to appear on the skin)
Alopecia (absence of hair from areas of the body)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Neuropathy peripheral (surface nerve damage)
Onychomadesis (a periodic idiopathic shedding of the nails)

50-59:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Scar
Skin discolouration (change of skin colour)
Skin hyperpigmentation (disorders affect the colour of your skin)
Skin hypertrophy (skin cells enlarges)
Skin tightness
Arthralgia (joint pain)
Deformity (disfigurement)
General physical health deterioration (weak health status)
Lichenification (thickening and hardening of the skin)

60+:

Asthenia (weakness)
Dry skin
Nodule on extremity (a small rock or mineral cluster on hands or legs)
Oedema (fluid collection in tissue)
Pain
Pain in extremity
Pruritus (severe itching of the skin)
Rash papular (redness with papule)
Skin hyperpigmentation (disorders affect the colour of your skin)
Skin hypertrophy (skin cells enlarges)

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Brain: 10 people, 23.81%
Joint Pain: 9 people, 21.43%
Catheter Related Complication: 8 people, 19.05%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 6 people, 14.29%
Anaemia (lack of blood): 5 people, 11.90%
High Blood Pressure: 4 people, 9.52%
Renal Osteodystrophy (a bone disease occurs when the kidneys fail to maintain the proper levels of calcium and phosphorus in the blood): 3 people, 7.14%
Pain: 3 people, 7.14%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 3 people, 7.14%
Headache (pain in head): 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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