Invokamet and Pain - a phase IV clinical study of FDA data

Summary:

Pain is reported as a side effect among people who take Invokamet (canagliflozin; metformin hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Invokana, and have Diabetes.

The phase IV clinical study analyzes which people have Pain when taking Invokamet. It is created by eHealthMe based on reports of 1,957 people who have side effects when taking Invokamet from the FDA, and is updated regularly.

What is Invokamet?

Invokamet has active ingredients of canagliflozin; metformin hydrochloride. eHealthMe is studying from 1,965 Invokamet users. Check the latest studies of Invokamet.

What is Pain?

Pain is found to be associated with 3,806 drugs and 5,872 conditions by eHealthMe. Check the latest studies of Pain.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 26, 2026

1,957 people reported to have side effects when taking Invokamet.
Among them, 30 people (1.53%) have Pain.

Among these 30 people:

How long have people been on Invokamet when they have Pain? *

What is the gender of people who have Pain when taking Invokamet? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Pain when taking Invokamet? *

What are other drugs people take besides Invokamet? *

What are other side effects people have besides Pain? *

Nausea (feeling of having an urge to vomit): 7 people, 23.33%
Fatigue (feeling of tiredness): 6 people, 20.00%
Blood Glucose Increased: 5 people, 16.67%
Stress And Anxiety: 5 people, 16.67%
Gait Disturbance: 5 people, 16.67%
Osteopenia (a condition where bone mineral density is lower than normal): 4 people, 13.33%
Depression: 4 people, 13.33%
Emotional Distress: 4 people, 13.33%
Multiple Fractures: 4 people, 13.33%
Bone Density Decreased: 4 people, 13.33%

What are the existing conditions these people have? *

Diabetes: 9 people, 30.00%
High Blood Pressure: 5 people, 16.67%
Hiv Infection: 4 people, 13.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 13.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 13.33%
Neuropathy Peripheral (surface nerve damage): 4 people, 13.33%
Cushing's Syndrome (obesity, a rounded face, increased fat): 3 people, 10.00%
Nausea (feeling of having an urge to vomit): 3 people, 10.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 10.00%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 3 people, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Invokamet and have Pain?

- Check whether Pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Invokamet:

Invokamet (1,965 reports)

Pain treatments and more:

Pain (1,140,596 reports)

How severe was Pain and when was it recovered:

Pain in Invokamet

Expand to all the drugs that have ingredients of canagliflozin; metformin hydrochloride:

Pain and drugs with ingredients of canagliflozin; metformin hydrochloride (31 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Invokamet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pain:

Pain (3,806 drugs)

Browse all the conditions that are associated with Pain:

Pain (5,872 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on canagliflozin; metformin hydrochloride (the active ingredients of Invokamet) and Invokamet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.