Fetzima and Hydroxyzine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fetzima (levomilnacipran hydrochloride) and Hydroxyzine (hydroxyzine hydrochloride). Common drug interactions include joint stiffness among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Fetzima and Hydroxyzine. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Fetzima?

Fetzima has active ingredients of levomilnacipran hydrochloride. It is often used in depression. eHealthMe is studying from 2,077 Fetzima users. Check the latest studies of Fetzima.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,069 Hydroxyzine users. Check the latest studies of Hydroxyzine.

On Jul, 17, 2026

62 people who take Fetzima and Hydroxyzine together, and have interactions are studied.

Fetzima and Hydroxyzine drug interactions.

What are the common drug interactions of Fetzima and Hydroxyzine, by gender? *:

female:

Joint stiffness
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Rash pruritic (redness with itching)
Cystitis interstitial (unknown cause characterized by bladder pain)
Ear disorder
Hypertension (high blood pressure)
Muscle spasms (muscle contraction)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sjogren's syndrome (a disease that causes dryness in the mouth and eyes)

male:

Pain
Fatigue (feeling of tiredness)
Psychomotor hyperactivity (feelings of extreme restlessness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Therapeutic response unexpected
Tooth loss
Dehydration (dryness resulting from the removal of water)
Malaise (a feeling of general discomfort or uneasiness)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone density decreased

What are the common drug interactions of Fetzima and Hydroxyzine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dehydration (dryness resulting from the removal of water)
Abdominal discomfort
Attention deficit/hyperactivity disorder
Brain injury
Cartilage injury
Depressed mood
Dyskinesia (abnormality or impairment of voluntary movement)
Emotional distress
Energy increased
Erectile dysfunction

30-39:

Dry skin
Rash pruritic (redness with itching)

40-49:

Blood cholesterol increased
Cardiac failure congestive
Cardiomyopathy (weakening of the heart muscle)
Death
Injection site erythema (redness at injection site)
Injection site swelling
Injection site urticaria (rash of round, red welts on the skin at injection site)
Injection site warmth
Joint stiffness
Muscular weakness (muscle weakness)

50-59:

Headache (pain in head)
Nasopharyngitis (inflammation of the nasopharynx)
Neuralgia (pain in one or more nerves)
Therapeutic response unexpected
Vertebral foraminal stenosis (narrowing of the intervertebral foramen)
Blood iron decreased
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Vomiting
Drug hypersensitivity
Fatigue (feeling of tiredness)

60+:

Dizziness
Tardive dyskinesia (a disorder that involves involuntary movements)
Vision blurred
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Retinal dystrophy (progressive weakness and wasting of the retina)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 27 people, 43.55%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 19 people, 30.65%
Insomnia (sleeplessness): 8 people, 12.90%
Pain: 7 people, 11.29%
Itching: 6 people, 9.68%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 9.68%
Drowsiness: 6 people, 9.68%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 4 people, 6.45%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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