Ranolazine and Keppra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ranolazine (ranolazine) and Keppra (levetiracetam). Common drug interactions include abdominal discomfort among females and malaise among males.

The phase IV clinical study analyzes what interactions people have when they take Ranolazine and Keppra. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Ranolazine?

Ranolazine has active ingredients of ranolazine. eHealthMe is studying from 9,939 Ranolazine users. Check the latest studies of Ranolazine.

What is Keppra?

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.



On Jul, 17, 2026

19 people who take Ranolazine and Keppra together, and have interactions are studied.

Ranolazine and Keppra drug interactions.

What are the common drug interactions of Ranolazine and Keppra, by gender? *:

female:

  1. Abdominal discomfort
  2. Diarrhoea
  3. Memory impairment
  4. Balance disorder
  5. Headache (pain in head)
  6. Myalgia (muscle pain)
  7. Psychotic disorder
  8. Suicidal ideation
  9. Vision blurred
  10. Femoral neck fracture (neck of femur bone fracture)

male:

  1. Malaise (a feeling of general discomfort or uneasiness)
  2. Arthralgia (joint pain)
  3. Back pain
  4. Dyspnoea (difficult or laboured respiration)
  5. Fatigue (feeling of tiredness)
  6. Haematochezia (passage of stools containing blood)
  7. Spinal cord injury lumbar (spinal cord injury at lumbar vertebrae region)
  8. Vision blurred
  9. Weight decreased
  10. Abnormal behaviour

What are the common drug interactions of Ranolazine and Keppra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Arthralgia (joint pain)
  2. Blood creatine phosphokinase increased
  3. Malaise (a feeling of general discomfort or uneasiness)
  4. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
  5. Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  6. Vomiting
  7. Brain stem glioma (cancerous glioma tumour in the brainstem)
  8. Decreased appetite
  9. Diarrhoea

20-29:

n/a

30-39:

n/a

40-49:

  1. Overdose

50-59:

n/a

60+:

  1. Vision blurred
  2. Back pain
  3. Abnormal behaviour
  4. Acute left ventricular failure (heart attack)
  5. Acute myocardial infarction (acute heart attack)
  6. Acute respiratory failure
  7. Aggression
  8. Anger
  9. Balance disorder
  10. Chronic kidney disease

What are the existing conditions these people have? *

  1. Stable Angina (a constant chest pain): 5 people, 26.32%
  2. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 5 people, 26.32%
  3. High Blood Cholesterol: 3 people, 15.79%
  4. Abdominal Discomfort: 2 people, 10.53%
  5. Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands): 2 people, 10.53%
  6. Parkinson's Disease: 2 people, 10.53%
  7. Pain: 2 people, 10.53%
  8. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 10.53%
  9. Back Pain: 2 people, 10.53%
  10. Brain Stem Glioma (cancerous glioma tumour in the brainstem): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Ranolazine and Keppra?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Ranolazine and Keppra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ranolazine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Keppra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ranolazine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Keppra and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on ranolazine and levetiracetam (the active ingredients of Ranolazine and Keppra, respectively), and Ranolazine and Keppra (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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