Oxycodone hydrochloride and Guaifenesin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Oxycodone hydrochloride (oxycodone hydrochloride) and Guaifenesin (guaifenesin). Common drug interactions include abdominal pain among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Oxycodone hydrochloride and Guaifenesin. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Oxycodone hydrochloride?

Oxycodone hydrochloride has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 36,817 Oxycodone hydrochloride users. Check the latest studies of Oxycodone hydrochloride.

What is Guaifenesin?

Guaifenesin has active ingredients of guaifenesin. It is often used in cough. eHealthMe is studying from 12,106 Guaifenesin users. Check the latest studies of Guaifenesin.

On Jul, 17, 2026

33 people who take Oxycodone hydrochloride and Guaifenesin together, and have interactions are studied.

Oxycodone hydrochloride and Guaifenesin drug interactions.

What are the common drug interactions of Oxycodone Hydrochloride and Guaifenesin, by gender? *:

female:

Abdominal pain
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood pressure decreased
Blood pressure increased
Cataract (clouding of the lens inside the eye)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Colitis ulcerative (inflammation of colon with ulcer)
Confusional state
Contusion (a type of hematoma of tissue in which capillaries)

male:

Fatigue (feeling of tiredness)
Drug dependence
Carotid artery stenosis (narrowing of carotid artery)
Constipation
Drug intolerance (drug sensitivity)
Hallucination (an experience involving the perception of something not present)
Heart rate increased
Hepatotoxicity (chemical-driven liver damage)
Impulse-control disorder
Malaise (a feeling of general discomfort or uneasiness)

What are the common drug interactions of Oxycodone Hydrochloride and Guaifenesin, by age (0-1 to 60+)? *:

0-1:

Body temperature decreased
Catheter site haemorrhage (bleeding at catheter site)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Death
Dyspnoea (difficult or laboured respiration)
Ear infection
Erythema (redness of the skin)
Furuncle (infection of the hair follicle)
Heart rate decreased
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)

2-9:

n/a

10-19:

n/a

20-29:

Fatigue (feeling of tiredness)
Hair colour changes
Skin disorder (skin disease)
Skin exfoliation (removal of the oldest dead skin cells)

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Emotional distress
Fracture

40-49:

Constipation
Nausea (feeling of having an urge to vomit)
Anxiety
Asthma
Carotid artery stenosis (narrowing of carotid artery)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Completed suicide (act of taking one's own life)
Depression
Drug dependence
Drug intolerance (drug sensitivity)

50-59:

Productive cough
Road traffic accident
Sinus pain
Sinusitis (inflammation of sinus)
Thyroid cancer recurrent (reoccurs thyroid cancer)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Upper respiratory tract infection
Urinary tract infection
Vulvovaginal mycotic infection (vulvovaginal fungal infection)
Pyrexia (fever)

60+:

Fatigue (feeling of tiredness)
Pneumonia
Confusional state
Depression
Device related infection
Dizziness
Ear infection fungal
Glossodynia (a burning or painful sensation in the tongue)
Headache (pain in head)
Herpes virus infection

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 5 people, 15.15%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 12.12%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 12.12%
Sleep Disorder: 2 people, 6.06%
Multiple Myeloma (cancer of the plasma cells): 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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