Vraylar and Linzess drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vraylar (cariprazine hydrochloride) and Linzess (linaclotide). Common drug interactions include haemorrhage intracranial among females and confusional state among males.

The phase IV clinical study analyzes what interactions people have when they take Vraylar and Linzess. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Vraylar?

Vraylar has active ingredients of cariprazine hydrochloride. eHealthMe is studying from 6,136 Vraylar users. Check the latest studies of Vraylar.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

On Jul, 17, 2026

46 people who take Vraylar and Linzess together, and have interactions are studied.

What are the common drug interactions of Vraylar and Linzess, by gender? *:

female:

Haemorrhage intracranial (bleeding within the skull)
Headache (pain in head)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypoaesthesia (reduced sense of touch or sensation)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Hypovolaemic shock (shock caused by severe blood or fluid loss)
Increased appetite
Injection site pain
Knee arthroplasty
Malaise (a feeling of general discomfort or uneasiness)

male:

Confusional state
Encephalopathy (functioning of the brain is affected by some agent or condition)
Angiopathy (generic term for a disease of the blood vessels)
Anxiety
Arthralgia (joint pain)
Asthenia (weakness)
Chest pain
Decreased appetite
Disturbance in attention
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Vraylar and Linzess, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Angiopathy (generic term for a disease of the blood vessels)
Anxiety
Arthralgia (joint pain)
Asthenia (weakness)
Chest pain
Depression
Disturbance in attention
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Hypersensitivity

30-39:

Confusional state
Encephalopathy (functioning of the brain is affected by some agent or condition)
Lung disorder (lung disease)
Somnolence (a state of near-sleep, a strong desire for sleep)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Ankylosing spondylitis (type of arthritis affecting the spine)
Blood cholesterol increased
Cerebral salt-wasting syndrome (low blood sodium concentration in brain)
Contusion (a type of hematoma of tissue in which capillaries)
Dyspnoea (difficult or laboured respiration)

40-49:

Chronic kidney disease
Depression
Knee arthroplasty
Post procedural infection
Suicidal ideation

50-59:

Migraine (headache)
Weight increased
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Back pain
Cough
Diarrhoea
Dry mouth
Insomnia (sleeplessness)
Oral discomfort (pain or irritation in mouth)
Tinnitus (a ringing in the ears)

60+:

Abdominal pain upper
Aphasia (damage to the parts of the brain that control language)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Vitamin d deficiency
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Decreased appetite
Fatigue (feeling of tiredness)
Haemorrhage intracranial (bleeding within the skull)
Migraine (headache)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 26.09%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 15.22%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 13.04%
Asthma: 4 people, 8.70%
Stress And Anxiety: 3 people, 6.52%
Insomnia (sleeplessness): 3 people, 6.52%
Hypersensitivity: 3 people, 6.52%
Drowsiness: 3 people, 6.52%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 3 people, 6.52%
Bipolar Disorder (mood disorder): 3 people, 6.52%

* Approximation only. Some reports may have incomplete information.

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