Fetzima and Prozac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fetzima (levomilnacipran hydrochloride) and Prozac (fluoxetine hydrochloride). Common drug interactions include hypertension among females and blood cholesterol increased among males.

The phase IV clinical study analyzes what interactions people have when they take Fetzima and Prozac. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Fetzima?

Fetzima has active ingredients of levomilnacipran hydrochloride. It is often used in depression. eHealthMe is studying from 2,077 Fetzima users. Check the latest studies of Fetzima.

What is Prozac?

Prozac has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 82,988 Prozac users. Check the latest studies of Prozac.

On Jul, 16, 2026

66 people who take Fetzima and Prozac together, and have interactions are studied.

What are the common drug interactions of Fetzima and Prozac, by gender? *:

female:

Hypertension (high blood pressure)
Back pain
Fatigue (feeling of tiredness)
Heart rate increased
Palpitations (feelings or sensations that your heart is pounding or racing)
Drug ineffective
Arthralgia (joint pain)
Chest discomfort
Discomfort
Joint swelling

male:

Blood cholesterol increased
Blood pressure increased
Hallucination (an experience involving the perception of something not present)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Constipation
Fatigue (feeling of tiredness)
Heart rate increased
Nausea (feeling of having an urge to vomit)
Nightmare (unpleasant dream)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

What are the common drug interactions of Fetzima and Prozac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Headache (pain in head)
Ventricular extrasystoles (premature cardiac contraction)
Vitamin d deficiency
Blood cholesterol increased
Drug ineffective
Dermatillomania (skin picking disorders)
Hallucination (an experience involving the perception of something not present)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Vaginal haemorrhage (vaginal bleeding)

30-39:

Arthralgia (joint pain)
Back pain
Chest discomfort
Discomfort
Fatigue (feeling of tiredness)
Heart rate increased
Hypertension (high blood pressure)
Joint swelling
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Neck pain

40-49:

n/a

50-59:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Hypersensitivity
Sinus congestion (blockage of sinus)
Snoring

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)
Hypophagia (reduced food intake)
Insomnia (sleeplessness)
Neuralgia (pain in one or more nerves)
Parkinson's disease
Abnormal dreams
Ageusia (loss of taste functions of the tongue)
Arrhythmia (irregular heartbeat)
Back injury

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 35 people, 53.03%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 20 people, 30.30%
Ankylosing Spondylitis (type of arthritis affecting the spine): 8 people, 12.12%
Insomnia (sleeplessness): 6 people, 9.09%
Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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