Fetzima and Spiriva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fetzima (levomilnacipran hydrochloride) and Spiriva (tiotropium bromide monohydrate). Common drug interactions include dyspnoea among females and insomnia among males.

The phase IV clinical study analyzes what interactions people have when they take Fetzima and Spiriva. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Fetzima?

Fetzima has active ingredients of levomilnacipran hydrochloride. It is often used in depression. eHealthMe is studying from 2,077 Fetzima users. Check the latest studies of Fetzima.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 17, 2026

31 people who take Fetzima and Spiriva together, and have interactions are studied.

What are the common drug interactions of Fetzima and Spiriva, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Irritability
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)
Agitation (state of anxiety or nervous excitement)
Back pain
Blood pressure increased
Gastritis (inflammation of stomach)
Headache (pain in head)
Heart rate increased

male:

Insomnia (sleeplessness)
Allergy test positive
Wheezing (a high-pitched whistling sound made while you breath)
Aphonia (inability to produce voice)
Crying
Death
Diarrhoea
Drug ineffective
Dry skin
Erythema annulare (redness of the skin with sign of inflammation or infection)

What are the common drug interactions of Fetzima and Spiriva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Bipolar disorder (mood disorder)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Death
Insomnia (sleeplessness)
Pemphigoid (tense blisters on the skin)
Post-traumatic stress disorder
Rash macular (small, flat red spots)

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)
Logorrhoea (excessive, uncontrollable, or incoherent talkativeness)
Urinary tract infection
Abnormal dreams
Arrhythmia (irregular heartbeat)
Insomnia (sleeplessness)
Aphonia (inability to produce voice)
Back injury
Cataract (clouding of the lens inside the eye)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 19 people, 61.29%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 12 people, 38.71%
Stress And Anxiety: 3 people, 9.68%
Pain: 2 people, 6.45%
High Blood Cholesterol: 2 people, 6.45%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 6.45%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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