Fioricet and Apixaban drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fioricet (acetaminophen; butalbital; caffeine) and Apixaban (apixaban). Common drug interactions include pulmonary embolism among females.

The phase IV clinical study analyzes what interactions people have when they take Fioricet and Apixaban. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Fioricet?

Fioricet has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 12,423 Fioricet users. Check the latest studies of Fioricet.

What is Apixaban?

Apixaban has active ingredients of apixaban. It is often used in blood clots. eHealthMe is studying from 60,351 Apixaban users. Check the latest studies of Apixaban.

On Jul, 26, 2026

11 people who take Fioricet and Apixaban together, and have interactions are studied.

Fioricet and Apixaban drug interactions.

What are the common drug interactions of Fioricet and Apixaban, by gender? *:

female:

Pulmonary embolism (blockage of the main artery of the lung)
Depression
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Blood creatinine increased
Blood disorder
Brain injury
Burning sensation
Chest pain
Confusional state

male:

n/a

What are the common drug interactions of Fioricet and Apixaban, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Glycosylated haemoglobin increased
Lymphocyte count decreased
Nausea (feeling of having an urge to vomit)
Chronic kidney disease
Blood creatinine increased
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Pulmonary embolism (blockage of the main artery of the lung)
Renal injury (kidney injury)
Respiratory failure (inadequate gas exchange by the respiratory system)

50-59:

Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
May-thurner syndrome (a rarely diagnosed condition in which patients develop iliofemoral deep venous thrombosis (dvt) due to an anatomical variant)
Memory impairment
Thrombosis (formation of a blood clot inside a blood vessel)
Vertigo
Blood disorder
Brain injury
Chest pain
Confusional state

60+:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Burning sensation

What are the existing conditions these people have? *

Pain: 4 people, 36.36%
Headache (pain in head): 2 people, 18.18%
High Blood Pressure: 2 people, 18.18%
High Blood Cholesterol: 2 people, 18.18%
Drowsiness: 1 person, 9.09%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 9.09%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 9.09%
Bacterial Infection: 1 person, 9.09%
Bone Disorder: 1 person, 9.09%
Bone Marrow Conditioning Regimen: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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