Fioricet and Colchicine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fioricet (acetaminophen; butalbital; caffeine) and Colchicine (colchicine). Common drug interactions include chronic kidney disease among females and hospitalisation among males.

The phase IV clinical study analyzes what interactions people have when they take Fioricet and Colchicine. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Fioricet?

Fioricet has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 12,423 Fioricet users. Check the latest studies of Fioricet.

What is Colchicine?

Colchicine has active ingredients of colchicine. It is often used in gout. eHealthMe is studying from 21,826 Colchicine users. Check the latest studies of Colchicine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

22 people who take Fioricet and Colchicine together, and have interactions are studied.

Fioricet and Colchicine drug interactions.

What are the common drug interactions of Fioricet and Colchicine, by gender? *:

female:

Chronic kidney disease
Pyrexia (fever)
Accident
Disability
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Pain
Chest pain
Cough
Dementia alzheimer's type (loss of mental ability with alzheimer's symptom)

male:

Hospitalisation
Abdominal pain
Plasma cell myeloma (cancer that begins in plasma cells)
Platelet count decreased
Rectal haemorrhage (bleeding from anus)
Shock haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding)
Vomiting
Portal hypertension (increase in the blood pressure within a system of veins called the portal venous system)
Bleeding varicose vein
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

What are the common drug interactions of Fioricet and Colchicine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Hospitalisation

40-49:

n/a

50-59:

Abdominal pain
Portal hypertension (increase in the blood pressure within a system of veins called the portal venous system)
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Arthralgia (joint pain)
Behcet's syndrome (involves inflammation of the blood vessels)
Cellulitis (infection under the skin)
Fall
Injection site erythema (redness at injection site)
Injection site pain
Injection site reaction

60+:

Dementia alzheimer's type (loss of mental ability with alzheimer's symptom)
Therapeutic response unexpected
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chills (felling of cold)
Dyspnoea (difficult or laboured respiration)
Fluid retention (an abnormal accumulation of fluid in the blood)
Haematochezia (passage of stools containing blood)
Haemoglobin decreased
Hypoxia (low oxygen in tissues)
International normalised ratio decreased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 22.73%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 22.73%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 18.18%
Headache (pain in head): 3 people, 13.64%
Sleep Disorder: 2 people, 9.09%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 9.09%
Pain: 2 people, 9.09%
Immunodeficiency Common Variable: 2 people, 9.09%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 9.09%
Chest Pain: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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