Fioricet and Pradaxa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fioricet (acetaminophen; butalbital; caffeine) and Pradaxa (dabigatran etexilate mesylate). Common drug interactions include myalgia among females and gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Fioricet and Pradaxa. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Fioricet?

Fioricet has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 12,423 Fioricet users. Check the latest studies of Fioricet.

What is Pradaxa?

Pradaxa has active ingredients of dabigatran etexilate mesylate. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 86,906 Pradaxa users. Check the latest studies of Pradaxa.

On Jul, 15, 2026

50 people who take Fioricet and Pradaxa together, and have interactions are studied.

What are the common drug interactions of Fioricet and Pradaxa, by gender? *:

female:

Myalgia (muscle pain)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Depression
Pneumonia
Fatigue (feeling of tiredness)
Suicidal ideation
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Weight increased
Hospitalisation
Infection

male:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Thrombosis (formation of a blood clot inside a blood vessel)
Haemorrhagic anaemia (anaemia due to excessive bleeding)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Subdural haematoma (blood collects between the skull and the surface of the brain)

What are the common drug interactions of Fioricet and Pradaxa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Fatigue (feeling of tiredness)
Food poisoning (poison in food)
Gastrointestinal infection (infection of stomach and intestine)
Myalgia (muscle pain)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nausea (feeling of having an urge to vomit)
Otitis media (inflammation of the middle ear)
Pain
Poor venous access
Productive cough

40-49:

Insomnia (sleeplessness)
Pyrexia (fever)
Skin discolouration (change of skin colour)
Pneumonia
Adverse drug reaction
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Fatigue (feeling of tiredness)
Infusion site bruising
Infusion site pain

50-59:

Thrombosis (formation of a blood clot inside a blood vessel)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Contusion (a type of hematoma of tissue in which capillaries)
Fatigue (feeling of tiredness)
Feeling hot
Impaired gastric emptying
Infection
Infusion related reaction
Infusion site erythema (reddening of the skin at infusion site)

60+:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemorrhagic anaemia (anaemia due to excessive bleeding)
Localised infection (infection at the single location)
Lower respiratory tract infection bacterial
Pneumonia
Respiratory tract infection
Scoliosis (a medical condition in which a person's spine is curved from side to side)
Sinusitis (inflammation of sinus)
Urinary tract infection
Abdominal pain

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 11 people, 22.00%
Stiff Person Syndrome: 10 people, 20.00%
Pain: 7 people, 14.00%
Stress And Anxiety: 3 people, 6.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 6.00%
High Blood Pressure: 3 people, 6.00%
Headache (pain in head): 3 people, 6.00%
Chest Pain: 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

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