Fiorinal and Paxil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fiorinal (aspirin; butalbital; caffeine) and Paxil (paroxetine hydrochloride). Common drug interactions include personality disorder among females and somnolence among males.

The phase IV clinical study analyzes what interactions people have when they take Fiorinal and Paxil. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Fiorinal?

Fiorinal has active ingredients of aspirin; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 2,714 Fiorinal users. Check the latest studies of Fiorinal.

What is Paxil?

Paxil has active ingredients of paroxetine hydrochloride. It is often used in depression. eHealthMe is studying from 92,546 Paxil users. Check the latest studies of Paxil.

On Jul, 16, 2026

63 people who take Fiorinal and Paxil together, and have interactions are studied.

What are the common drug interactions of Fiorinal and Paxil, by gender? *:

female:

Personality disorder
Pulmonary hypertension (increase in blood pressure in the lung artery)
Respiratory failure (inadequate gas exchange by the respiratory system)
Retching (strong involuntary effort to vomit)
Sleep disorder
Somatisation disorder (a long-term (chronic) condition in which a person has physical symptoms that involve more than one part of the body)
Somnolence (a state of near-sleep, a strong desire for sleep)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Viral pharyngitis (inflammation of the throat or pharynx caused by viral infection)
Weight decreased

male:

Somnolence (a state of near-sleep, a strong desire for sleep)
Asthenia (weakness)
Nervousness
Weight decreased
Blood glucose increased
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Drug maladministration
Embolic stroke (stroke due to obstruction due to an embolus)
Fatigue (feeling of tiredness)
Hyperthermia (body temperature greatly above normal)

What are the common drug interactions of Fiorinal and Paxil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Accident
Drug dependence
Influenza like illness
Injection site pain
Injection site reaction
Injury
Malaise (a feeling of general discomfort or uneasiness)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nuclear magnetic resonance imaging brain

30-39:

Nervousness
Weight decreased
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body)
Asthenia (weakness)
Completed suicide (act of taking one's own life)
Death
Depressed mood
Disturbance in attention
Dizziness

40-49:

Memory impairment
Nausea (feeling of having an urge to vomit)
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting
Arthralgia (joint pain)
Asthma
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Cardiovascular disorder (heart diseases)
Chest pain

50-59:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dysarthria (speech disorder)
Dyspnoea (difficult or laboured respiration)
Embolic stroke (stroke due to obstruction due to an embolus)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Influenza
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Panic attack

60+:

Oedema peripheral (superficial swelling)
Dyspnoea (difficult or laboured respiration)
Malaise (a feeling of general discomfort or uneasiness)
Pneumonia
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Upper respiratory tract infection
Anaemia (lack of blood)
Hypersensitivity
Lung infection
Nasal obstruction (blockage of nose)

What are the existing conditions these people have? *

Pain: 8 people, 12.70%
Stress And Anxiety: 6 people, 9.52%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 9.52%
Headache (pain in head): 6 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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