Fiorinal and Zopiclone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fiorinal (aspirin; butalbital; caffeine) and Zopiclone (eszopiclone). Common drug interactions include colitis ulcerative among females and multiple sclerosis relapse among males.

The phase IV clinical study analyzes what interactions people have when they take Fiorinal and Zopiclone. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Fiorinal?

Fiorinal has active ingredients of aspirin; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 2,714 Fiorinal users. Check the latest studies of Fiorinal.

What is Zopiclone?

Zopiclone has active ingredients of eszopiclone. It is often used in insomnia. eHealthMe is studying from 54,330 Zopiclone users. Check the latest studies of Zopiclone.

On Jul, 20, 2026

11 people who take Fiorinal and Zopiclone together, and have interactions are studied.

Fiorinal and Zopiclone drug interactions.

What are the common drug interactions of Fiorinal and Zopiclone, by gender? *:

female:

Colitis ulcerative (inflammation of colon with ulcer)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Diarrhoea
Eye disorder
Fatigue (feeling of tiredness)
Glycosylated haemoglobin increased
Haematochezia (passage of stools containing blood)
Lymphocyte count decreased
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Pain

male:

Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)

What are the common drug interactions of Fiorinal and Zopiclone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal discomfort
Abdominal pain
Arthralgia (joint pain)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Diarrhoea
Haematochezia (passage of stools containing blood)
Stress

40-49:

n/a

50-59:

Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Cardiac tamponade (fluid accumulates in heart covering)
Pericardial effusion (fluid around the heart)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

60+:

Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Colitis ulcerative (inflammation of colon with ulcer)
Fatigue (feeling of tiredness)
Glycosylated haemoglobin increased
Lymphocyte count decreased
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
White blood cell count increased

What are the existing conditions these people have? *

Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 4 people, 36.36%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 18.18%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 18.18%
Joint Pain: 2 people, 18.18%
Headache (pain in head): 2 people, 18.18%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 1 person, 9.09%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 1 person, 9.09%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 9.09%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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