Flagyl and Amoxil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flagyl (metronidazole) and Amoxil (amoxicillin). Common drug interactions include impaired healing among females and ear infection among males.

The phase IV clinical study analyzes what interactions people have when they take Flagyl and Amoxil. It is created by eHealthMe based on reports of 76 people who take the same drugs from the FDA, and is updated regularly.

What is Flagyl?

Flagyl has active ingredients of metronidazole. It is often used in vaginitis bacterial. eHealthMe is studying from 25,897 Flagyl users. Check the latest studies of Flagyl.

What is Amoxil?

Amoxil has active ingredients of amoxicillin. It is often used in infection. eHealthMe is studying from 3,641 Amoxil users. Check the latest studies of Amoxil.

On Jul, 15, 2026

76 people who take Flagyl and Amoxil together, and have interactions are studied.

What are the common drug interactions of Flagyl and Amoxil, by gender? *:

female:

Impaired healing
Muscular weakness (muscle weakness)
Osteonecrosis of jaw (death of bone of jaw)
Toothache (tooth pain)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Cellulitis streptococcal (deep skin soft tissue infection by bacteria)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Death
Decreased appetite

male:

Ear infection
Upper respiratory tract infection
Anxiety
Bipolar disorder (mood disorder)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Eczema eyelids (patches of skin become rough and inflamed, with itching and bleeding blisters on eyelid)
Lung neoplasm (tumour of lung)
Reflux oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus)
Rhinitis allergic (inflammation of the nasal airways due to allergy)

What are the common drug interactions of Flagyl and Amoxil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Anxiety
Attention deficit/hyperactivity disorder
B-cell lymphoma (blood cancer affecting b cells)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Conjunctivitis (pink eye)
Cough
Depression
Ear infection
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Eczema eyelids (patches of skin become rough and inflamed, with itching and bleeding blisters on eyelid)

10-19:

Abdominal pain upper
Adenoidal hypertrophy (enlarged adenoids)
Drug ineffective
Ear pain
Eye pain
Fluid intake reduced
Hypophagia (reduced food intake)
Oropharyngeal pain
Pain
Pharyngeal haemorrhage (pharyngeal bleeding)

20-29:

Maternal exposure during pregnancy (use of substance during pregnancy)
Cardiac disorder
Menometrorrhagia (a condition in which prolonged or excessive uterine bleeding occurs irregularly and more frequently than normal)
Migraine (headache)
Type 1 diabetes mellitus
Asthma
Cardiac failure congestive
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Ectopic pregnancy (a pregnancy in which the foetus develops outside the uterus, typically in a fallopian tube)
Hypertension (high blood pressure)

30-39:

Drug hypersensitivity
Contusion (a type of hematoma of tissue in which capillaries)
Dependence
Drug diversion
Overdose
Asthenia (weakness)
Dysmenorrhoea (painful menstruation)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Oedema peripheral (superficial swelling)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

40-49:

Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Abdominal pain
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Arthropathy
Asthenia (weakness)
Asthma
Blood pressure increased

50-59:

Alanine aminotransferase increased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aphasia (damage to the parts of the brain that control language)
Aspartate aminotransferase increased
Blood glucose increased
Bone disorder
Bone pain
Cellulitis streptococcal (deep skin soft tissue infection by bacteria)
Chronic kidney disease

60+:

Anxiety
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Muscular weakness (muscle weakness)
Nausea (feeling of having an urge to vomit)
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Urinary tract infection
Abdominal pain upper
Actinomycosis (infection that causes sores, or abscesses)

What are the existing conditions these people have? *

Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 8 people, 10.53%
Multiple Myeloma (cancer of the plasma cells): 5 people, 6.58%
Osteoporosis (bones weak and more likely to break): 4 people, 5.26%
Indigestion: 4 people, 5.26%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 5.26%
Fever: 4 people, 5.26%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 5.26%
Anaemia (lack of blood): 4 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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